2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester

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2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester manufacturers
2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester Basic information
Product Name:2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester
Synonyms:2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester;2,5-Dihydro-2-(4-hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2-furancarboxylic acid methyl ester;2,5-Dihydro-4-hydroxy-2-(4-hydroxybenzyl)-3-(4-hydroxyphenyl)-5-oxofuran-2-carboxylic acid methyl ester;2-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-3-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-5-oxo-, methyl ester, (2R)-;Butyrolactone II
CAS:87414-44-6
MF:C19H16O7
MW:356.33
EINECS:
Product Categories:Antibiotic
Mol File:87414-44-6.mol
2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester Structure
2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester Chemical Properties
Melting point 91-94 °C
Boiling point 640.5±55.0 °C(Predicted)
density 1.497±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Amorphous.
pka8.61±0.40(Predicted)
color White to off-white
Safety Information
HS Code 29419000
MSDS Information
2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester Usage And Synthesis
DescriptionButyrolactone II is a butenolide fungal metabolite that has been found in A. terreus. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and ABTS free radicals (EC50s = 11.5 and 68.5 μM, respectively). It inhibits 5-lipoxygenase (5-LO; IC50 = 21.43 μg/ml) and α-glucosidase (IC50 = 0.126 mM).
UsesButyrolactone II is an antibiotic, a 5-LOX inhibitor and has shown DPPH radical-scavening activity.
IC 50Microbial Metabolite
storage+4°C
References[1] HAHK-SOO KANG  Jong P K. Butenolide derivatives from the fungus Aspergillus terreus and their radical scavenging activity and protective activity against glutamate-induced excitotoxicity[J]. Applied Biological Chemistry, 2019, 62 1. DOI: 10.1186/s13765-019-0451-3
[2] FU-SHENG WANG B Z. Butyrolactones, inhibitors of 5-lipoxygenase from fungal metabolites[J]. Journal of Chinese Pharmaceutical Sciences, 2010, 19 1. DOI: 10.5246/jcps.2010.04.035
[3] LI-HUA ZHANG . Polyketide butenolide, diphenyl ether, and benzophenone derivatives from the fungus Aspergillus flavipes PJ03-11[J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26 2: Pages 346-350. DOI: 10.1016/j.bmcl.2015.12.009
2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester Preparation Products And Raw materials
Tag:2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester(87414-44-6) Related Product Information
KANAMYCIN B SULFATE [5R,(+)]-5-[(S)-1-Hydroxyethyl]-3-[(2S)-3-methyloxirane-2-yl]furan-2(5H)-one CYTOCHALASIN C lydicamycin Geneticin Lincomycin hydrochloride monohydrate acetomycin Streptomycin sulfate geninthiocin (S)-(+)-Ascochin Cefotaxime sodium MALFORMINC Kanamycin sulfate Clindamycin hydrochloride ANTIMYCIN A Tobramycin gallidermin 2,5-Dihydro-furan-2-carboxylic acid