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- Geninthiocin A
-
- $791.00
-
2026-05-11
- CAS:158792-27-9
- Purity:
- Supply Ability: 10g
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| | geninthiocin Basic information |
| Product Name: | geninthiocin | | Synonyms: | geninthiocin;14-DeMethylberinaMycin;PubChem ID: 16129809;Geninthiocin A;Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (7→1)-... | | CAS: | 158792-27-9 | | MF: | C50H49N15O15S | | MW: | 1132.08 | | EINECS: | | | Product Categories: | | | Mol File: | 158792-27-9.mol |  |
| | geninthiocin Chemical Properties |
| density | 1.54±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: soluble; DMSO: soluble; Ethanol: slightly soluble | | form | White to off-white amorphous powder. | | pka | 10.01±0.60(Predicted) |
| | geninthiocin Usage And Synthesis |
| Description | Geninthiocin A is a cyclic thiopeptide bacterial metabolite originally isolated from Streptomyces sp. DD84. It is active against a variety of Gram-positive bacteria (MICs = 0.2-4 μg/ml), the Gram-negative bacterium C. violaceum (MIC = 19 μg/ml), and the fungus M. hiemalis (MIC = 38 μg/ml). Geninthiocin A also induces tipA promoter transcription with a minimum induction concentration of 1.2 ng/ml. | | Uses | Geninthiocin, a thiopeptide antibiotic isolated from a Streptomyces sp., is a potent activator of the tipA gene, a bacterial transcription regulator involved in multidrug resistance. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines, whereas the related dedialanyl geninthiocin shows the reverse selectivity. Geninthiocin is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1. | | Uses | Geninthiocin is a thiopeptide antibiotic tipA gene activator. | | References | [1] B S YUN. Microbial metabolites with tipA promoter inducing activity. II. Geninthiocin, a novel thiopeptide produced by Streptomyces sp. DD84.[J]. Journal of Antibiotics, 1994, 47 9: 969-975. DOI: 10.7164/antibiotics.47.969
[2] APPADURAI MUTHAMIL INIYAN. Ala-geninthiocin, a new broad spectrum thiopeptide antibiotic, produced by a marine Streptomyces sp. ICN19[J]. Journal of Antibiotics, 2018, 72 2: 99-105. DOI: 10.1038/s41429-018-0115-2 |
| | geninthiocin Preparation Products And Raw materials |
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