2,4,8-Trichloroquinazoline manufacturers
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| | 2,4,8-Trichloroquinazoline Basic information |
| | 2,4,8-Trichloroquinazoline Chemical Properties |
| Boiling point | 309.1±24.0 °C(Predicted) | | density | 1.60 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -1.68±0.30(Predicted) | | Appearance | White to yellow Solid |
| | 2,4,8-Trichloroquinazoline Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2,4,8-trichloroquinazoline from 8-chloroquinazoline-2,4(1H,3H)-dione: (1041) To 8-chloroquinazoline-2,4(1H,3H)-dione (3.8 g, 19.33 mmol) was added 60 mL of phosphorus oxychloride (POCl3). The reaction mixture was heated to reflux for 16 hours. Upon completion of the reaction, the excess phosphorous trichloride was evaporated under reduced pressure and the residue was purified by column chromatography to afford 2,4,8-trichloroquinazoline (3.11 g, 76% yield). Mass spectrum (ESI+): m/z = 233 [M + 1]. | | References | [1] Patent: US2016/168140, 2016, A1. Location in patent: Paragraph 1041
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 10, p. 2297 - 2300
[3] Patent: US5688803, 1997, A
[4] Patent: EP2226315, 2010, A1. Location in patent: Page/Page column 33
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 12, p. 5141 - 5156 |
| | 2,4,8-Trichloroquinazoline Preparation Products And Raw materials |
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