| Company Name: |
amyjet |
| Tel: |
4006800868;027-59626688 18771149750 |
| Email: |
sales@amyjet.com |
|
| | (±)9,10-DiHOME-d4 Basic information |
| | (±)9,10-DiHOME-d4 Chemical Properties |
| solubility | DMF: 20 mg/ml DMSO: 20 mg/ml Ethanol: 20 mg/mlPBS (pH 7.2): 10 µg/ml |
| | (±)9,10-DiHOME-d4 Usage And Synthesis |
| Description | (±)9(10)-DiHOME-d4 is intended for use as an internal standard for the quantification of 9(10)-DiHOME by GC- or LC-MS. (±)9(10)-DiHOME is the diol form of (±)9(10)-EpOME (Item No. 52400), a cytochrome P450-derived epoxide of linoleic acid (Item Nos. 90150 | 90150.1 | 21909) also known as leukotoxin.1 It is formed from 9(10)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils.2WARNING This product is not for human or veterinary use. | | References | [1] JESSICA F. GREENE. Metabolism of Monoepoxides of Methyl Linoleate: Bioactivation and Detoxification[J]. Archives of biochemistry and biophysics, 2000, 376 2: Pages 420-432. DOI: 10.1006/abbi.2000.1753 [2] MEHRAN F. MOGHADDAM. Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase[J]. Nature Medicine, 1997, 3 5: 562-566. DOI: 10.1038/nm0597-562 [3] LAURA KUTZNER. Development of an Optimized LC-MS Method for the Detection of Specialized Pro-Resolving Mediators in Biological Samples.[J]. Frontiers in Pharmacology, 2019: 169. DOI: 10.3389/fphar.2019.00169 |
| | (±)9,10-DiHOME-d4 Preparation Products And Raw materials |
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