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| | (±)12,13-DiHOME Basic information |
| Product Name: | (±)12,13-DiHOME | | Synonyms: | (±)12,13-DiHOME;9-Octadecenoic acid, 12,13-dihydroxy-, (9Z)-;(±)12(13)-DiHOME MaxSpec Standard | | CAS: | 263399-35-5 | | MF: | C18H34O4 | | MW: | 314.46 | | EINECS: | | | Product Categories: | | | Mol File: | 263399-35-5.mol |  |
| | (±)12,13-DiHOME Chemical Properties |
| Boiling point | 476.0±30.0 °C(Predicted) | | density | 1.015±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 10 μ g/ml | | pka | 4.78±0.10(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | (±)12,13-DiHOME Usage And Synthesis |
| Uses | (±)-12,13-DIHOME is an exercise induced lipokine which has been shown to induce skeletal muscle fatty acid uptake. May be used in the treatment of neuropathic pain. | | Definition | ChEBI: 12,13-DiHOME is a DiHOME obtained by formal dihydroxylation of the 12,13-double bond of octadeca-9,12-dienoic acid (the 9Z-geoisomer). It is a conjugate acid of a 12,13-DiHOME(1-). | | in vivo | 12,13-DiHOME (1 μg/kg; retro-orbitally injection; once daily for 2 weeks) acutely decreases levels of serum triglycerides in mice with high-fat diet model, and increases BAT uptake to defend cold[1].
| Animal Model: | Mice fed a high-fat diet[1] | | Dosage: | 1 μg/kg | | Administration: | Retro-orbitally injection; once daily for 2 weeks | | Result: | Displayed no effects on body weight, glucose tolerance or circulating nonesterified FA.
Increased BAT-specific lipid uptake and improved oral lipid tolerance.
Increased radiolabeled FA uptake (Fig. 3f) and glucose uptake. |
| Animal Model: | To explore the biosynthesis of (±)12, 13-dihome in mice in vivo[1] | | Dosage: | | | Administration: | 7-d cold challenge in mice: mice treated with norepinephrine (NE) for 30 min and exposed to 4°C-cold for 1 h | | Result: | Result: Increased in the circulation of male mice exposed to cold, but not female mice. And also, the enzymes producing 12,13-diHOME were uniquely induced in BAT by cold stimulation. |
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| | (±)12,13-DiHOME Preparation Products And Raw materials |
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