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| | CAY10505 Basic information |
| Product Name: | CAY10505 | | Synonyms: | (5E)-5-{[5-(4-fluorophenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione;5-((5-(4-Fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-;POSH-IN-1 | | CAS: | 328960-84-5 | | MF: | C14H8FNO3S | | MW: | 289.28 | | EINECS: | | | Product Categories: | | | Mol File: | 328960-84-5.mol |  |
| | CAY10505 Chemical Properties |
| density | 1.466±0.06 g/cm3(Predicted) | | solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.15 mg/ml | | form | A crystalline solid | | pka | 6.21±0.20(Predicted) |
| | CAY10505 Usage And Synthesis |
| Description | Phosphoinositide 3-kinase γ (PI3Kγ), expressed primarily in hematopoietic cells, plays several important roles in immunity. CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the γ isoform (IC50 = 30 nM) better than the α, β, and δ isoforms (IC50 = 0.94, 20, and 20 μM, respectively).1 Tested against a panel of 80 other kinases, CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages (IC50 = 228 nM).1 Oral administration of CAY10505 reduces neutrophil recruitment in mice to an extent that is comparable to that observed in PI3Kγ-deficient mice.1 | | Uses | POSH-IN-1 (Compound 108) is an inhibitor for POSH polypeptide, that inhibits the ubiquitin ligase of POSH with an IC50 of 900 nM[1]. | | References | 1. Pomel, V., Klicic, J., Covini, D., et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ J. Med. Chem. 49(13),3857-3871(2006). |
| | CAY10505 Preparation Products And Raw materials |
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