138794-73-7
| 中文名称 | 138794-73-7 |
|---|---|
| 中文同义词 | 2-(4-甲脒基-2,3-二氢-1H-茚-1-亚基)肼-1-甲脒基二盐酸盐;化合物SARDOMOZIDE;SARDOMOZIDE 盐酸盐,10 MM DMSO 溶液;二甲双胍杂质55;Sardomozide二盐酸盐 |
| 英文名称 | CGP 48664A |
| 英文同义词 | CGP 48664A;Sardomozide HCl;Sardomozide dihydrochloride;2-(4-Carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazine-1-carboximidamide dihydrochloride;Sardomozide HCl (SAM-486A or CGP-48664);Sardomozide (hydrochloride);CGP 48664 dihydrochloride|||Sardomozide dihydrochloride;Sardomozide dihydrochloride, 10 mM in DMSO |
| CAS号 | 138794-73-7 |
| 分子式 | C11H15ClN6 |
| 分子量 | 266.73 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 138794-73-7.mol |
| 结构式 |  |
138794-73-7 性质
| 储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| 溶解度 | DMSO:25.0(最大浓度 mg/mL);82.46(最大浓度 mM) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| InChI | 1S/C11H14N6/c12-10(13)8-3-1-2-7-6(8)4-5-9(7)16-17-11(14)15/h1-3H,4-5H2,(H3,12,13)(H4,14,15,17)/b16-9+ |
| InChIKey | CYPGNVSXMAUSJY-CXUHLZMHSA-N |
| SMILES | NC(C1=CC=CC2=C1CC/C2=N\NC(N)=N)=N.Cl.Cl |
Sardomozide dihydrochloride 是一种 S-腺苷甲硫氨酸脱羧酶 (SAMDC) 抑制剂，其 IC50 值为 5 nM。
IC50: 5 nM (SAMDC)
Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC 50 of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-13746B | Sardomozide dihydrochloride | 138794-73-7 | 1 mg | 670元 |
| 2025/12/22 | HY-13746B | 138794-73-7 Sardomozide dihydrochloride | 138794-73-7 | 5mg | 1147元 |