| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
GPI 15427 manufacturers
- GPI-15427
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- $2500.00
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2026-05-11
- CAS:805242-85-7
- Purity:
- Supply Ability: 10g
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| | GPI 15427 Basic information |
| Product Name: | GPI 15427 | | Synonyms: | GPI 15427;DZRLVSOGARUEGQ-UHFFFAOYSA-N;[1]Benzopyrano[4,3,2-de]phthalazin-3(2H)-one, 10-[(4-methyl-1-piperazinyl)methyl]- | | CAS: | 805242-85-7 | | MF: | C20H20N4O2 | | MW: | 348.4 | | EINECS: | | | Product Categories: | | | Mol File: | 805242-85-7.mol |  |
| | GPI 15427 Chemical Properties |
| | GPI 15427 Usage And Synthesis |
| Uses | GPI 15427 is a potent inhibitor of the enzyme poly (ADP-ribose) polymerase-1 (PARP-1), which plays a harmful role during inflammation. In a rat model of gut injury and inflammation, including splanchnic artery occlusion (SAO) shock and dinitrobenzene sulfonic acid (DNBS)-induced colitis, GPI 15427 demonstrated strong anti-inflammatory effects. It reduced inflammatory cell infiltration, histological injury, and delayed clinical signs of inflammation. GPI 15427 also diminished the accumulation of poly (ADP-ribose) in the ileum and colon of treated rats. These results suggest GPI 15427 could be useful for treating intestinal ischemia and inflammation[1]. | | References | [1] Treatment with PARP-1 inhibitors, GPI 15427 or GPI 16539, ameliorates intestinal damage in rat models of colitis and shock |
| | GPI 15427 Preparation Products And Raw materials |
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