J-147
| 中文名称 | J-147 |
|---|---|
| 中文同义词 | 2,2,2-三氟乙酸 1-(2,4-二甲基苯基)-2-[(3-甲氧基苯基)亚甲基]酰肼;化合物J147;J-147,神经源性和神经保护性姜黄素衍生物;N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE;化合物J147,10 MM DMSO 溶液;J147 J-147 CP级 99% 10G 100G 1KG;(E/Z)-J147试剂;(E/Z)-J147试剂 |
| 英文名称 | J 147 |
| 英文同义词 | J147/J-147;2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide;J 147;N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE;J 147 2,2,2-Trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide;Nootropic J147;CS-1446;J-147?, >98% |
| CAS号 | 1146963-51-0 |
| 分子式 | C18H17F3N2O2 |
| 分子量 | 350.33 |
| EINECS号 | 1592732-453-0 |
| 相关类别 | 抑制剂;小分子抑制剂;小分子抑制剂，天然产物;产品;Inhibitors;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 1146963-51-0.mol |
| 结构式 |  |
J-147 性质
| 沸点 | 412.8±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.18±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | DMSO:68.0(最大浓度 mg/mL);194.1(最大浓度 mM) |
| 形态 | 粉末 |
| 酸度系数(pKa) | 0.80±0.50(Predicted) |
| 颜色 | 米白色至粉红色 |
| InChI | InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3 |
| InChIKey | HYMZAYGFKNNHDN-UHFFFAOYSA-N |
| SMILES | C(N(C1=CC=C(C)C=C1C)N=CC1=CC=CC(OC)=C1)(=O)C(F)(F)F |
MAO B; Dopamine transporter
J-147 promotes HT22 and primary cell survival in a dose-dependent manner (EC 50 value range of 0.06-0.115 μM) .
J-147 (diet is prepared by the addition of J-147 at 200ppm; 6 months) enhances memory and dendritic spine number in old mice.
The half life (t
1/2
) of J-147 is calculated at 1.5 hrs in plasma and 2.5 hrs in brain ( per oral (PO) administration at a single dose of 20 mg/kg).
| Animal Model: | 24 male C57Bl/6 mice aged 24 months; using 8 month-old mice as controls |
| Dosage: | 200 ppm |
| Administration: | The diet was prepared by the addition of 200ppm; 6 months |
| Result: | While both young and old animals recognized when an object was moved a large distance (135 degrees), a reduction in the recognition index (RI) in aged mice was observed when the object was moved a smaller distance of 45 degrees. The reduction in the RI was reversed upon treatment with J147. |
391646-35-8
407-25-0
1146963-51-0
在0℃及氮气保护下，向搅拌的1-(2,4-二甲基苯基)-2-[(3-甲氧基苯基)亚甲基]酰肼（500mg，1.97mmol）和三乙胺（0.33mL，2.36mmol）的二氯甲烷（5mL）溶液中缓慢滴加三氟乙酸酐（0.33mL，2.36mmol）。反应混合物在0℃下持续搅拌1.5小时。反应完成后，将混合物浓缩，残余物通过柱色谱法使用丙酮/己烷（1:10）作为洗脱剂进行纯化，得到目标产物2,2,2-三氟乙酸1-(2,4-二甲基苯基)-2-[(3-甲氧基苯基)亚甲基]酰肼（571mg，收率83%），为浅黄色油状物。1H NMR（CDCl3）数据如下：δ7.26-7.23（m，4H），7.19（d，J = 8.0Hz，1H），7.12（d，J = 7.5Hz，1H），7.03（d，J = 8.0Hz，1H），6.92（dd，J = 8.5,2.0Hz，1H），3.79（s，3H），2.39（s，3H），2.08（s，3H）。高分辨质谱（ESI-TOF，m/z）分析结果：C18H18N2O2F3（[M + H]+）的计算值为351.1320；实测值为351.1311。
参考文献：
[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 2, p. 524 - 527
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-13779 | N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE J-147 | 1146963-51-0 | 10mM * 1mLin DMSO | 385元 |
| 2025/05/22 | HY-13779 | N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE J-147 | 1146963-51-0 | 5mg | 500元 |