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| | AF12198 Basic information |
| Product Name: | AF12198 | | Synonyms: | AF12198;AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-AZE-TYR-ALA-LEU-PRO-LEU-NH2;AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBONYL-TYR-ALA-LEU-PRO-LEU-NH2;AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBOXYLIC ACID-TYR-ALA-LEU-PRO-LEU-NH2;L-Leucinamide, N-acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-;Ac-FEWTPGWYQ（Aze）YALPL-NH2;AF12198（TFA）;AF12198, human type I interleukin receptor antagonist | | CAS: | 185413-30-3 | | MF: | C96H123N19O22 | | MW: | 1895.12 | | EINECS: | | | Product Categories: | | | Mol File: | 185413-30-3.mol |  |
| | AF12198 Chemical Properties |
| Melting point | >179°C (dec.) | | density | 1.353±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO (Slightly), Methanol (Slightly), Water (Very Slightly) | | form | solid | | pka | 4.44±0.10(Predicted) | | color | White to Off-White | | Sequence | Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-{Aze}-Tyr-Ala-Leu-Pro-Leu-NH2 |
| | AF12198 Usage And Synthesis |
| Uses | AF 12198 is a peptide that selectively binds Interleukin-1 (IL-1) receptor and blocks in vivo responses to IL-1 (1). The interleukin-1 receptor can activate the innate immune response by binding to cytokines (2). Dysregulation of cytokine production can lead to aberrant immune cells activation that could result in auto-inflammatory disorders. | | in vivo | AF12198 (intravenous infusion; 16 mg/kg; 30 min before LPS intravenous injection) significantly attenuates the increase in lung MPO activity induced by LPS in acute lung inflammation and it reduces the lung microvascular leakage from rats inflamed with LPS at the 4 h (32.6%), 12 h (50.1%) and 24 h (65.3%) after LPS[2]. | Animal Model: | Male Wistar rats[2] | | Dosage: | 16mg/kg | | Administration: | Intravenous infusion; 30min before LPS intravenous injection | | Result: | Decreased pulmonary microvascular leakage in rats. |
| | IC 50 | IL-6; IL-8; IL1R1: 8 nM (IC50) | | storage | Store at -20°C |
| | AF12198 Preparation Products And Raw materials |
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