OrfaMide B

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OrfaMide B Basic information
Product Name:OrfaMide B
Synonyms:OrfaMide B;L-Valine, N-(3-hydroxy-1-oxotetradecyl)-L-leucyl-D-α-glutamyl-D-allothreonyl-D-valyl-L-leucyl-D-seryl-L-leucyl-L-leucyl-D-seryl-, (10→3)-lactone
CAS:939960-35-7
MF:C63H112N10O17
MW:1281.62
EINECS:
Product Categories:
Mol File:939960-35-7.mol
OrfaMide B Structure
OrfaMide B Chemical Properties
solubility DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form A solid
Safety Information
MSDS Information
OrfaMide B Usage And Synthesis
DescriptionOrfamide B is a cyclic lipopeptide originally isolated from P. fluorescens. It is the main orfamide produced by Pseudomonas sp. CMR12a. Orfamide B inhibits mycelial growth and increases hyphal branching in the fungi R. solani AG2-1 at concentrations of 10 and 100 μM and in R. solani AG 4-HGI at a concentration of 100 μM.
UsesOrfamide B is a component of a family of cyclic lipopeptides produced by Pseudomonas fluorescens, reported in 2007. The orfamides were discovered by employing genomic analysis with an isotope-guided fractionation to identify metabolites produced by orphan gene clusters containing non-ribosomal peptide synthetases. Orfamide B has not been further investigated, although its activity is thought to parallel that of orfamide A and other cyclic lipopeptides produced by Pseudomonas.
UsesOrfamide B is a cyclic lipopeptide produced by Pseudomonas fluorescens.
References[1] HARALD GROSS. The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters.[J]. Chemistry & biology, 2007, 14 1: 53-63. DOI: 10.1016/j.chembiol.2006.11.007
[2] FEYISARA EYIWUMI OLORUNLEKE. Interplay between orfamides, sessilins and phenazines in the control of Rhizoctonia diseases by Pseudomonas sp. CMR12a[J]. Environmental Microbiology Reports, 2015, 7 5: 774-781. DOI: 10.1111/1758-2229.12310
OrfaMide B Preparation Products And Raw materials
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