ITD 1
| 中文名称 | ITD 1 |
|---|---|
| 中文同义词 | 4-[1,1'-联苯]-4-基-1,4,5,6,7,8-六氢-2,7,7-三甲基-5-氧代-3-喹啉羧酸乙酯;4-([1,1'-联苯]-4-基)-2,7,7-三甲基-5-氧代-1,4,5,6,7,8-六氢喹啉-3-羧酸乙酯;化合物ITD1;ITD 1 (TGF-Β RECEPTOR抑制剂);ITD-1,TGF-Β信号传导的抑制剂;化合物ITD1,10 MM DMSO 溶液;4-[1,1'-联苯]-4-基-1,4,5,6,7,8-六氢-2,7,7-三甲基-5-氧代-3-喹啉羧酸乙酯;ITD-1 ,S6713 |
| 英文名称 | ITD-1 |
| 英文同义词 | ITD-1;4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester;AOB6123;SCHEMBL3239096;ETHYL 4-{[1,1'-BIPHENYL]-4-YL}-2,7,7-TRIMETHYL-5-OXO-1,4,6,8-TETRAHYDROQUINOLINE-3-CARBOXYLATE;ITD1;ITD-1;ITD 1;CS-1731;3-Quinolinecarboxylic acid, 4-[1,1'-biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-, ethyl ester |
| CAS号 | 1099644-42-4 |
| 分子式 | C27H29NO3 |
| 分子量 | 415.52 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;抑制剂;Inhibitors |
| Mol文件 | 1099644-42-4.mol |
| 结构式 |  |
ITD 1 性质
| 沸点 | 569.9±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.18±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO 中≥28.05 mg/mL；不溶于水；不溶于乙醇 |
| 形态 | 固体 |
| 酸度系数(pKa) | 1.33±0.70(Predicted) |
| 颜色 | 浅黄至黄色 |
| Target | Value |
|
TGF-β
() |
ITD-1 potently blocks phosphorylation of the effector SMAD2/3 proteins induced by TGFβ2, and only minimally in response to Activin A. HEK293T cells are transfected with a Smad4 response element driving luciferase (SBE4-Luc) to test whether ITD-1 blocks Activin A/Nodal and/or TGFβ signaling, which utilize the same intracellular signaling cascade through Smad4. ITD-1 strongly inhibits TGFβ2 signaling with similar efficacy (92% vs. 99% respectively), but with lower potency compared to SB-431542, an ACVR1B/TGFBR1 kinase inhibitor (IC 50 = 850nM vs. 70nM respectively), and is a weak and partial inhibitor of Activin A signals. ITD-1 selectively enhances the differentiation of uncommitted mesoderm to cardiomyocytes, but not to vascular smooth muscle and endothelial cells. ITD-1 reveals an unexpected role for TGFβ signaling in controlling cardiomyocyte differentiation from multipotent cardiovascular precursors .
141-97-9
126-81-8
3218-36-8
1099644-42-4
以对苯基苯甲醛（1 mmol）、5,5-二甲基-1,3-环己二酮（0.14 g，1 mmol）、乙酰乙酸乙酯（0.13 g，1 mmol）、乙酸铵（0.115 g，1.5 mmol）和Fe2O3（催化量）负载于羟基磷灰石（HAP，催化量）上为原料，加入三聚氰胺（0.15 g）作为助剂，在80℃下加热反应。反应进程通过薄层色谱（TLC，展开剂为正己烷/乙酸乙酯，体积比10:3）进行监测。反应完成后，将反应混合物冷却至室温，用热乙酸乙酯洗涤，并通过磁力分离去除催化剂。将固体残余物分离，并通过在热乙醇中重结晶进行纯化，得到目标产物4-([1,1'-联苯]-4-基)-2,7,7-三甲基-5-氧代-1,4,5,6,7,8-六氢喹啉-3-羧酸乙酯。
参考文献：
[1] RSC Advances, 2014, vol. 4, # 101, p. 57662 - 57670
[2] Research on Chemical Intermediates, 2015, vol. 41, # 10, p. 7227 - 7244
[3] Applied Organometallic Chemistry, 2016, vol. 30, # 5, p. 311 - 317
[4] Journal of Coordination Chemistry, 2017, vol. 70, # 2, p. 340 - 360
[5] Synthetic Communications, 2017, vol. 47, # 12, p. 1185 - 1191
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-12704 | ITD-1 | 1099644-42-4 | 1 mg | 360元 |
| 2025/12/22 | HY-12704 | ITD 1 ITD-1 | 1099644-42-4 | 5mg | 700元 |