| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
Itacitinib adipate manufacturers
|
| | Itacitinib adipate Basic information |
| Product Name: | Itacitinib adipate | | Synonyms: | INCB39110;2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile INCB39110;Itacitinib adipate;3-azetidineacetonitrile, 1-[1-[[3-fluoro-2-(trifluoromethyl)-4-pyridinyl]carbonyl]-4-piperidinyl]-3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)-1h-pyrazol-1-yl]-,hexanedioic acid salt;Itacitinib adipate (INCB 39110 adipate);2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile adipate | | CAS: | 1334302-63-4 | | MF: | C32H33F4N9O5 | | MW: | 699.67 | | EINECS: | | | Product Categories: | | | Mol File: | 1334302-63-4.mol |  |
| | Itacitinib adipate Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: ≥ 137.5 mg/mL (196.52 mM) | | form | Solid | | color | White to off-white |
| | Itacitinib adipate Usage And Synthesis |
| Uses | Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis. | | IC 50 | JAK1 | | References | [1] Griesshammer M, et al. The BCR-ABL1-negative myeloproliferative neoplasms: a review of JAK inhibitors in the therapeutic armamentarium. Expert Opin Pharmacother. 2017 Dec;18(18):1929-1938. DOI:10.1080/14656566.2017.1404574 |
| | Itacitinib adipate Preparation Products And Raw materials |
|