二羟基喹酮
| 中文名称 | 二羟基喹酮 |
|---|---|
| 中文同义词 | 1,2,3,4-四氢-6-硝基-2,3-二氧苯并[F]喹喔啉-7-磺钠盐水合物;6 -硝基- 7 - 硫氨基苯并[F]喹喔啉-2,3二酮;二羟基喹酮;1,2,3,4-四氢-6-硝基-2,3-二氧代苯并[F]喹喔啉-7-磺酰胺;6-硝基-2,3-二氧代-1,2,3,4-四氢苯并[F]喹喔啉-7-磺酰胺;NBQXHYDRATEPOWDER,>=98%(HPLC);NBQX,AMPA /海藻酸盐拮抗剂;NBQX,AMPA / KAINATE拮抗剂 |
| 英文名称 | NBQX DISODIUM SALT |
| 英文同义词 | 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline;FG 9202, 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate;FG 9202 hydrate disodium salt, 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate disodium salt;NBQX hydrate disodium salt;2,3-Doxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline;FG 9202 disodium salt hydrate;2,3-Dihydroxy-6-nitrobenzo[f]quinoxaline-7-sulfonamide;6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3(1H,4H)-dione |
| CAS号 | 118876-58-7 |
| 分子式 | C12H8N4O6S |
| 分子量 | 336.28 |
| EINECS号 | |
| 相关类别 | 抑制剂;原料药;Glutamate;Glutamate receptor;Heterocyclic Compounds;Neurochemicals |
| Mol文件 | 118876-58-7.mol |
| 结构式 |  |
二羟基喹酮 性质
| 熔点 | 361°C |
|---|---|
| 密度 | 1.6027 (rough estimate) |
| 折射率 | 1.6000 (estimate) |
| 储存条件 | Inert atmosphere,2-8°C |
| 溶解度 | 溶于甲醇，溶解度为0.25mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 7.55±0.20(Predicted) |
| 颜色 | 粘黄色 |
| 水溶解性 | H2O: >10mg/mL |
| 稳定性 | -20℃冷冻保存 |
| InChI | InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22) |
| InChIKey | UQNAFPHGVPVTAL-UHFFFAOYSA-N |
| SMILES | N1C2=C(C3=CC=CC(S(N)(=O)=O)=C3C([N+]([O-])=O)=C2)NC(=O)C1=O |
NBQX (FG9202, NNC 079202) 是一种具有高选择性的 AMPA receptor (AMPAR) 的竞争性拮抗剂，具有抗癫痫的作用。
| Target | Value |
|
AMPAR
() |
NBQX (FG9202) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex.
NBQX (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ.
NBQX is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion.
| Animal Model: | Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ) |
| Dosage: | 20 mg/kg |
| Administration: | IP; for 3 days |
| Result: | Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats. |
| 提供商 | 语言 |
|---|---|
|
英文
|
|
|
英文
|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/07/06 | S9686 | 二羟基喹酮 NBQX (FG9202) | 118876-58-7 | 5mg | 1556.1元 |
| 2026/07/06 | S9686 | 二羟基喹酮 NBQX (FG9202) | 118876-58-7 | 25mg | 4668.3元 |