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| | 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylic acid Basic information |
| | 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylic acid Chemical Properties |
| storage temp. | 2-8°C | | Appearance | White to off-white Solid |
| | 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylic acid Usage And Synthesis |
| Synthesis | Methyl 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylate (2 g, crude) was used as a raw material, which was dissolved in a mixed solvent of ethanol (5 mL) and tetrahydrofuran (5 mL), followed by the addition of 2N sodium hydroxide solution (5 mL). The reaction mixture was stirred at 60°C for 2 hours. Upon completion of the reaction, the pH was adjusted to 1 with dilute hydrochloric acid and subsequently extracted with ethyl acetate. The organic phase was concentrated to give the pink solid product 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylic acid (300 mg, 15% yield, two steps). | | References | [1] Patent: WO2012/24150, 2012, A1. Location in patent: Page/Page column 130
[2] Patent: WO2012/27322, 2012, A1. Location in patent: Page/Page column 102
[3] Patent: WO2012/40139, 2012, A1. Location in patent: Page/Page column 100
[4] Patent: US2013/195879, 2013, A1. Location in patent: Paragraph 0266
[5] Patent: US2018/141923, 2018, A1. Location in patent: Paragraph 0474; 0477; 0478 |
| | 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylic acid Preparation Products And Raw materials |
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