| Company Name: |
T&W GROUP |
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021-61551611 13296011611 |
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contact@trustwe.com |
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| | HJC0152 Basic information |
| Product Name: | HJC0152 | | Synonyms: | 2-(2-Aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide HCl;HJC0152;2-(2-aminoethoxy)-5-chloro-N-(2-chloro-4-
nitrophenyl)benzamide hydrochloride;Benzamide, 2-(2-aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)-, hydrochloride (1:1);HJC0152 hydrochloride;HJC0152 HCl;Inhibitor,Apoptosis,HJC 0152,HJC0152 hydrochloride,inhibit,STAT,HJC-0152,HJC-0152 hydrochloride;HJC0152 hydrochloride, 10 mM in DMSO | | CAS: | 1420290-99-8 | | MF: | C15H14Cl3N3O4 | | MW: | 406.64836 | | EINECS: | | | Product Categories: | | | Mol File: | 1420290-99-8.mol |  |
| | HJC0152 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF:0.1(Max Conc. mg/mL);0.25(Max Conc. mM)
DMSO:30.33(Max Conc. mg/mL);74.59(Max Conc. mM) | | form | A crystalline solid | | color | Light yellow to yellow | | InChI | InChI=1S/C15H13Cl2N3O4.ClH/c16-9-1-4-14(24-6-5-18)11(7-9)15(21)19-13-3-2-10(20(22)23)8-12(13)17;/h1-4,7-8H,5-6,18H2,(H,19,21);1H | | InChIKey | XRZHLOYBZOONSZ-UHFFFAOYSA-N | | SMILES | Cl.NCCOC1C=CC(Cl)=CC=1C(NC1C=CC([N+]([O-])=O)=CC=1Cl)=O |
| | HJC0152 Usage And Synthesis |
| Uses | HJC0152 Hydrochloride, is a potent and orally bioavailable anticancer agent, significantly suppressing MDA-MB-231 xenograft tumor growth in vivo. | | in vivo | Mice treated with 7.5 mg/kg of HJC0152 (compound 11) via ip show a better effect in inhibiting tumor growth. The growth of xenograft tumors in mice is significantly reduced by HJC0152 at a dose of 25 mg/kg. It is also noteworthy that HJC0152 does not show significant signs of toxicity at a dose of 75 mg/kg[1]. | | IC 50 | STAT3 |
| | HJC0152 Preparation Products And Raw materials |
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