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| | YCNKUIFVRZSRNL-QZTJIDSGSA-N Basic information |
| Product Name: | YCNKUIFVRZSRNL-QZTJIDSGSA-N | | Synonyms: | YCNKUIFVRZSRNL-QZTJIDSGSA-N;BACE1-IN-2;BACE1IN2,BACE1 IN 2,BACE-1-IN-2;2-Pyridinecarboxamide, N-[3-[(2R,3R)-5-amino-3,6-dihydro-3-methyl-2-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-;N-[3-[(2R,3R)-5-Amino-3,6-dihydro-3-methyl-2-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-2-pyridinecarboxamide | | CAS: | 1352416-78-4 | | MF: | C19H15F4N5O2 | | MW: | 421.35 | | EINECS: | | | Product Categories: | | | Mol File: | 1352416-78-4.mol |  |
| | YCNKUIFVRZSRNL-QZTJIDSGSA-N Chemical Properties |
| density | 1.47±0.1 g/cm3(Predicted) | | pka | 9.98±0.70(Predicted) |
| | YCNKUIFVRZSRNL-QZTJIDSGSA-N Usage And Synthesis |
| Uses | BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC50 of 22 nM[1]. | | IC 50 | BACE1 | | References | [1] Gijsen HJM, et al. Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate. J Med Chem. 2018 Jun 28;61(12):5292-5303. DOI:10.1021/acs.jmedchem.8b00304 |
| | YCNKUIFVRZSRNL-QZTJIDSGSA-N Preparation Products And Raw materials |
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