8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione tris(hydroxylmethyl)aminomethane salt

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8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione tris(hydroxylmethyl)aminomethane salt manufacturers

  • GSK256073 Tris
  • GSK256073 Tris pictures
  • $2500.00
  • 2026-05-11
  • CAS:1228650-42-7
  • Purity:
  • Supply Ability: 10g
8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione tris(hydroxylmethyl)aminomethane salt Basic information
Product Name:8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione tris(hydroxylmethyl)aminomethane salt
Synonyms:8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione tris(hydroxylmethyl)aminomethane salt;GSK256073 Tris
CAS:1228650-42-7
MF:C10H13ClN4O2.C4H11NO3
MW:377.82
EINECS:
Product Categories:
Mol File:1228650-42-7.mol
8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione tris(hydroxylmethyl)aminomethane salt Structure
8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione tris(hydroxylmethyl)aminomethane salt Chemical Properties
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MSDS Information
8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione tris(hydroxylmethyl)aminomethane salt Usage And Synthesis
DescriptionGSK256073 is an agonist of G-protein coupled receptor 109A (GPR109A). It acts by reducing serum glucose in subjects with type 2 diabetes mellitus.
UsesGSK256073 tris is a potent, selective and orally active GPR109A agonist and a long-lasting and non-flushing HCA2 full agonist with a pEC50 of 7.5 (human HCA2). GSK256073 tris acutely improves glucose homeostasis via inhibition of lipolysis and has the potential for the study of type 2 diabetes mellitus (T2DM)and dyslipidemia[1][2]. GPR109A: G-protein coupled receptor 109A; HCA2: hydroxy-carboxylic acid receptor 2
References[1] Dobbins RL, et al. GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus.Diabetes Obes Metab.2013 Nov;15(11):1013-21. DOI:10.1111/dom.12132
[2] Sprecher D, et al. Discovery and characterization of GSK256073, a non-flushing hydroxy-carboxylic acid receptor 2 (HCA2) agonist.Eur J Pharmacol. 2015 Jun 5;756:1-7. DOI:10.1016/j.ejphar.2015.01.051
8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione tris(hydroxylmethyl)aminomethane salt Preparation Products And Raw materials
Tag:8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione tris(hydroxylmethyl)aminomethane salt(1228650-42-7) Related Product Information
ACIFRAN 3-Pyridinecarboxamide, N-[2-[[5-(1,2-dithiolan-3-yl)-1-oxopentyl]amino]ethyl]- 1H-Pyrazole-3-carboxylic acid, 5-ethyl-4-methyl- 1-Isopropyl-1H-1,2,3-benzotriazole-5-carboxylic acid (4aR,5aR)-4,4a,5,5a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxylic acid MK-6892