1-Isopropyl-1H-1,2,3-benzotriazole-5-carboxylic acid manufacturers
- IBC 293
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- $44.00
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2026-05-26
- CAS:306935-41-1
- Purity: 99.74%
- Supply Ability: 10g
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| | 1-Isopropyl-1H-1,2,3-benzotriazole-5-carboxylic acid Basic information |
| Product Name: | 1-Isopropyl-1H-1,2,3-benzotriazole-5-carboxylic acid | | Synonyms: | BUTTPARK 36\04-50;IBC 293;IPBT-5CA;1-ISOPROPYL-1H-BENZO[D][1,2,3]TRIAZOLE-5-CARBOXYLIC ACID;1-ISOPROPYL-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID;1-ISOPROPYLBENZOTRIAZOLE-5-CARBOXYLIC ACID;1-(1-METHYLETHYL)-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID;1-Isopropyl-1,2,3-benzotriazole-5-carboxylic acid | | CAS: | 306935-41-1 | | MF: | C10H11N3O2 | | MW: | 205.21 | | EINECS: | | | Product Categories: | | | Mol File: | 306935-41-1.mol |  |
| | 1-Isopropyl-1H-1,2,3-benzotriazole-5-carboxylic acid Chemical Properties |
| Melting point | 229-230°C | | Boiling point | 413.9±18.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | Soluble in DMSO (up to 25 mg/ml). | | pka | 3.50±0.30(Predicted) | | form | Light brown solid | | color | Off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | | CAS DataBase Reference | 306935-41-1(CAS DataBase Reference) |
| | 1-Isopropyl-1H-1,2,3-benzotriazole-5-carboxylic acid Usage And Synthesis |
| Description | IPBT-5CA (306935-41-1) is a highly selective agonist for the human orphan G-protein-coupled receptor GPR109b (EC50 = 400 nM). No activity was reported at the highly homologous high-affinity niacin receptor GPR109a. | | Uses | GPR109 receptor agonist-1 (Compound 3a) is a highly selective agonist of the human orphan G-protein-coupled receptor GPR109b, with the pEC50 of 6.4. GPR109 receptor agonist-1 can be used for the research of cardio-metabolic diseases[1]. | | Definition | ChEBI: 1-propan-2-yl-5-benzotriazolecarboxylic acid is a member of benzotriazoles. | | Biological Activity | Highly selective agonist for GPR109B (HM74), the human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over closely related niacin receptor GPR109A (HM74A); EC 50 values are 400 nM and > 1 μ M respectively. In vitro, inhibits isoproterenol-stimulated lipolysis in isolated human adipocytes. | | References | [1] GRAEME SEMPLE. 1-Alkyl-benzotriazole-5-carboxylic Acids Are Highly Selective Agonists of the Human Orphan G-Protein-Coupled Receptor GPR109b[J]. Journal of Medicinal Chemistry, 2006, 49 4: 1227-1230. DOI:10.1021/jm051099t |
| | 1-Isopropyl-1H-1,2,3-benzotriazole-5-carboxylic acid Preparation Products And Raw materials |
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