(T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron

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(T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
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Email: ivan@atkchemical.com
Products Intro: Product Name:TH1217
CAS:1862212-48-3
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
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Products Intro: Product Name:TH 1217
CAS:1862212-48-3
Purity:>=98%(HPLC) Package:$157.9/5mg;$256.9/10mg;$513.9/25mg;$820.9/50mg;Bulk package Remarks:98%(HPLC)
Company Name: Nanjing Dulai Biotechnology Co., Ltd.  
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Products Intro: Product Name:TH 1217
CAS:1862212-48-3
Purity:>=98%(HPLC) Package:50mg
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Products Intro: Product Name:TH 1217
CAS:1862212-48-3
Purity:98% by HPLC Package:1G;10G;100G Remarks:TH 1217 is a potent dCTPase pyrophosphatase 1 inhibitor with IC50 value of 47 nM.
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
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Products Intro: Product Name:TH 1217
CAS:1862212-48-3
Purity:>=98%(HPLC) Package:50mg Remarks:S57280
(T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron Basic information
Product Name:(T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron
Synonyms:2-[4-[[5,6-Dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl]methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione;TH 1217;(T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron;3,TH1217;Boron, [N-[(carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]-, (T-4)-;2-[4-[(5,6-Dichloro-2-methyl-4-nitrobenzimidazol-1-yl)methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
CAS:1862212-48-3
MF:C20H17BCl2N4O6
MW:491.09
EINECS:
Product Categories:
Mol File:1862212-48-3.mol
(T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron Structure
(T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron Chemical Properties
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
color White to off-white
Safety Information
MSDS Information
(T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron Usage And Synthesis
UsesTH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19[1][2].
storageStore at -20°C
References[1] Llona-Minguez S, et, al. Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. Med Chem. 2016 Feb 11; 59(3): 1140-1148. DOI:10.1021/acs.jmedchem.5b01741
[2] Gordon DE, et, al. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv. 2020 Mar 22; 2020.03.22.002386. DOI:10.1101/2020.03.22.002386
(T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron Preparation Products And Raw materials
Tag:(T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron(1862212-48-3) Related Product Information
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