| Company Name: |
Nanjing Dulai Biotechnology Co., Ltd.
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025-846993838003-8003 18013301590 |
| Email: |
njduly@126.com |
| Products Intro: |
Product Name:TH 1217
CAS:1862212-48-3
Purity:>=98%(HPLC) Package:50mg
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:TH 1217
CAS:1862212-48-3
Purity:98% by HPLC Package:1G;10G;100G Remarks:TH 1217 is a potent dCTPase pyrophosphatase 1 inhibitor with IC50 value of 47 nM.
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| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:TH 1217
CAS:1862212-48-3
Purity:>=98%(HPLC) Package:50mg Remarks:S57280
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| | (T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron Basic information |
| Product Name: | (T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron | | Synonyms: | 2-[4-[[5,6-Dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl]methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione;TH 1217;(T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron;3,TH1217;Boron, [N-[(carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]-, (T-4)- | | CAS: | 1862212-48-3 | | MF: | C20H17BCl2N4O6 | | MW: | 491.09 | | EINECS: | | | Product Categories: | | | Mol File: | 1862212-48-3.mol | ![(T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron Structure](CAS/20240320/GIF/1862212-48-3.gif) |
| | (T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | color | White to off-white |
| | (T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron Usage And Synthesis |
| Uses | TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19[1][2]. | | storage | Store at -20°C | | References | [1] Llona-Minguez S, et, al. Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. Med Chem. 2016 Feb 11; 59(3): 1140-1148. DOI:10.1021/acs.jmedchem.5b01741
[2] Gordon DE, et, al. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv. 2020 Mar 22; 2020.03.22.002386. DOI:10.1101/2020.03.22.002386 |
| | (T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron Preparation Products And Raw materials |
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