1H-Indole-3-carboxaldehyde, 2-(3,7-dimethyl-2-quinolinyl)hydrazone

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1H-Indole-3-carboxaldehyde, 2-(3,7-dimethyl-2-quinolinyl)hydrazone Suppliers list
Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
Tel: 025-85560043 13675144456
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Products Intro: Product Name:1H-Indole-3-carbaldehyde(3,7-dimethyl-2-quinolinyl)hydrazone
CAS:364361-68-2
Purity:95%HPLC Package:500mg;1g;5g;10g
Company Name: Cayman Chemical Company  
Tel: 800-364-9897
Email: sales@caymanchem.com
Products Intro: Product Name:Endosidin 5
CAS:364361-68-2
1H-Indole-3-carboxaldehyde, 2-(3,7-dimethyl-2-quinolinyl)hydrazone Basic information
Product Name:1H-Indole-3-carboxaldehyde, 2-(3,7-dimethyl-2-quinolinyl)hydrazone
Synonyms:1H-Indole-3-carbaldehyde(3,7-dimethyl-2-quinolinyl)hydrazone;1H-Indole-3-carboxaldehyde, 2-(3,7-dimethyl-2-quinolinyl)hydrazone
CAS:364361-68-2
MF:C20H18N4
MW:314.38
EINECS:
Product Categories:
Mol File:364361-68-2.mol
1H-Indole-3-carboxaldehyde, 2-(3,7-dimethyl-2-quinolinyl)hydrazone Structure
1H-Indole-3-carboxaldehyde, 2-(3,7-dimethyl-2-quinolinyl)hydrazone Chemical Properties
Boiling point 559.8±50.0 °C(Predicted)
density 1.22±0.1 g/cm3(Predicted)
solubility Acetonitrile: Slightly soluble: 0.1-1 mg/ml
DMSO: Sparingly soluble: 1-10 mg/ml
pka10.97±0.70(Predicted)
Safety Information
MSDS Information
1H-Indole-3-carboxaldehyde, 2-(3,7-dimethyl-2-quinolinyl)hydrazone Usage And Synthesis
UsesEndosidine 5 (ES5) inhibits EPS (extracellular polymeric substance) secretion and cell wall expansion. Endosidine 5 alters secretion of ECM (extracellular matrix) material in Penium margaritaceum by affecting the Golgi apparatus. Endosidine 5 interferes with recycling endosomes through Annexin A6, thereby promoting the release and expression of mRNA into the cytoplasm[1][2].
References[1] LoRicco JG, et al. Endosidin 5 disruption of the Golgi apparatus and extracellular matrix secretion in the unicellular charophyte Penium margaritaceum. Ann Bot. 2023 Jul 10;131(6):967-983. DOI:10.1093/aob/mcad054
[2] Shin J, et al. Targeting Recycling Endosomes to Potentiate mRNA Lipid Nanoparticles. Nano Lett. 2024 May 1;24(17):5104-5109. DOI:10.1021/acs.nanolett.3c04415
[3] GEORGIA DRAKAKAKI. Clusters of bioactive compounds target dynamic endomembrane networks in vivo.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 43: 17850-17855. DOI: 10.1073/pnas.1108581108
[4] SABIN LLONA-MINGUEZ . Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines[J]. Bioorganic & Medicinal Chemistry Letters, 2017, 27 16: Pages 3897-3904. DOI: 10.1016/j.bmcl.2017.06.038
1H-Indole-3-carboxaldehyde, 2-(3,7-dimethyl-2-quinolinyl)hydrazone Preparation Products And Raw materials
Tag:1H-Indole-3-carboxaldehyde, 2-(3,7-dimethyl-2-quinolinyl)hydrazone(364361-68-2) Related Product Information
H-8 DIHYDROCHLORIDE Endosidin 2 (T-4)-[N-[(Carboxy-κO)methyl]-N-methylglycinato(2-)-κN,κO][4-[(5,6-dichloro-2-methyl-4-nitro-1H-benzimidazol-1-yl)methyl]phenyl]boron h-e5'NT Inhibitor 5C 3-Isoxazolecarboxamide, N-[3-[4-[3-[3-(3-butyn-1-yl)-3H-diazirin-3-yl]-1-oxopropyl]-1-piperazinyl]propyl]-5-phenyl- A 11