卡立泊来德
| 中文名称 | 卡立泊来德 |
|---|---|
| 中文同义词 | 卡立泊来德;N-(氨基亚氨基甲基)-4-(1-甲基乙基)-3-(甲磺酰基)苯甲酰胺;N-(二氨基亚甲基)-4-异丙基-3-(甲磺酰基)苯甲酰胺;CARIPORIDE,NHE1抑制剂;卡立泊来德,10 MM DMSO 溶液;159138-80-4;Cariporide |
| 英文名称 | CARIPORIDE |
| 英文同义词 | CARIPORIDE;N-(diaminomethylene)-4-isopropyl-3-mesyl-benzamide;N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide;N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide;BenzaMide,N-(aMinoiMinoMethyl)-4-(1-Methylethyl)-3-(Methylsulfonyl)-;Cariporide (HOE-642);CS-1692;Sodium/hydrogen Exchanger,Na+/H+ Exchanger (NHE),inhibit,Sodium-hydrogen Exchanger,HOE642,Inhibitor,Cariporide,HOE 642 |
| CAS号 | 159138-80-4 |
| 分子式 | C12H17N3O3S |
| 分子量 | 283.35 |
| EINECS号 | 1592732-453-0 |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;合成材料中间体;Inhibitors |
| Mol文件 | 159138-80-4.mol |
| 结构式 |  |
卡立泊来德 性质
| 熔点 | 90-94° (dec) |
|---|---|
| 密度 | 1.34 |
| 储存条件 | 2-8°C |
| 溶解度 | 不溶于水； DMSO 中≥12.05 mg/mL；温和加热和超声波下，乙醇中≥2.675 mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| InChI | InChI=1S/C12H17N3O3S/c1-7(2)9-5-4-8(11(16)15-12(13)14)6-10(9)19(3,17)18/h4-7H,1-3H3,(H4,13,14,15,16) |
| InChIKey | IWXNYAIICFKCTM-UHFFFAOYSA-N |
| SMILES | C1(S(=O)(=O)C)=CC(=CC=C1C(C)C)C(=O)/N=C(\N)/N |
| Target | Value |
|
NHE1
(CHO-K1 cells) | 30 nM |
Cariporide significantly suppresses markers of cell death, such as TUNEL positivity and caspase-3 cleavage, at 8 or 16 hours. Cariporide remarkably suppresses cytosolic Na + and Ca 2+ accumulation. Cariporide prevents mitochondrial membrane potential loss induced by H 2+ O 2+ . Cariporide (HOE-642) ameliorates myocardial ischemia/reperfusion injury, by the well-established reduction of cytosolic Ca 2+ in cardiac myocytes through inhibition of Na + /H + exchange. Cariporide (HOE-642), has inhibitory effects on the degranulation of human platelets, the formation of platelet–leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1).
Intravenous administration of cariporide significantly decreases brain Na + uptake and reduces cerebral edema, brain swelling, and infarct volume.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| RTECS号 | CV2310560 |
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-19693 | 卡立泊来德 Cariporide | 159138-80-4 | 1 mg | 250元 |
| 2025/12/22 | HY-19693 | 卡立泊来德 Cariporide | 159138-80-4 | 5mg | 550元 |