PX 102

Request For Quotation
PX 102 Suppliers list
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Company Name: Jinan Yaoyan Pharmaceutical Co., Ltd.  
Tel:
Email: jnyaoyan@163.com
Company Name: Nanjing Meihao Pharmaceutical Technology Co., Ltd.  
Tel: meitaochem@126.com
Email: meitaochem@126.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
PX 102 Basic information
Product Name:PX 102
Synonyms:PX 102;CPD1220;Benzoic acid, 4-[2-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]cyclopropyl]-
CAS:1268245-19-7
MF:C29H22Cl3NO4
MW:554.85
EINECS:
Product Categories:
Mol File:1268245-19-7.mol
PX 102 Structure
PX 102 Chemical Properties
Safety Information
MSDS Information
PX 102 Usage And Synthesis
UsesPX20606 is an orally active agonist for farnesoid X receptor (FXR), with EC50 220 nM (mFXR) and 50 nM (hFXR), measured by Gal4-FXR assay. PX20606 induces the expression of tumor suppressor gene NDRG2, inhibits the tumor growth and metastasis in mouse HCC model. PX20606 exhibits hepatoprotective efficacy[1].
References[1] Deuschle U, et al., FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. PLoS One. 2012;7(10):e43044. DOI:10.1371/journal.pone.0043044
PX 102 Preparation Products And Raw materials
Raw materials3-Chlorophenol
Tag:PX 102(1268245-19-7) Related Product Information
3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)azetidin-3-ol hydrochloride (E)-3-(2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)styryl)benzoic acid Px-104 NA (E)-Methyl 3-(2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)styryl)benzoate 4-Isoxazolecarboxylic acid, 5-cyclopropyl-3-(2,6-dichlorophenyl)-, methyl ester