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5'-O-DMTr-N4-Fmoc-5-Me-dC-phosphoramidite manufacturers
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| | 5'-O-DMTr-N4-Fmoc-5-Me-dC-phosphoramidite Basic information |
| Product Name: | 5'-O-DMTr-N4-Fmoc-5-Me-dC-phosphoramidite | | Synonyms: | 5'-O-DMTr-N4-Fmoc-5-Me-dC-phosphoramidite;Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-5-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI);2'-Deoxy-5'-O-DMT-N4-Fmoc-5-methylcytidine 3'-CE-phosphoramidite;5’-O-DMTr-N4-Fmoc-5-Me-dC-phosphoramidite | | CAS: | 176755-87-6 | | MF: | C55H60N5O9P | | MW: | 966.08 | | EINECS: | | | Product Categories: | | | Mol File: | 176755-87-6.mol |  |
| | 5'-O-DMTr-N4-Fmoc-5-Me-dC-phosphoramidite Chemical Properties |
| solubility | DMSO: Sparingly Soluble: 1-10 mg/ml
Ethanol: Sparingly Soluble: 1-10 mg/ml | | pka | 6.38±0.40(Predicted) |
| | 5'-O-DMTr-N4-Fmoc-5-Me-dC-phosphoramidite Usage And Synthesis |
| Uses | 2'-Deoxy-5'-O-DMT-N4-Fmoc-5-methylcytidine 3'-CE-phosphoramidite is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1]. | | References | [1] Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8. DOI:10.4161/cbt.3.11.1308
[2] E. FERRER. Preparation of Oligonucleotides Containing 5-Bromouracil and 5-Methylcytidine.[J]. Nucleosides, Nucleotides & Nucleic Acids, 1996, 15 1: 907-921. DOI: 10.1080/07328319608002137 |
| | 5'-O-DMTr-N4-Fmoc-5-Me-dC-phosphoramidite Preparation Products And Raw materials |
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