N-(Azido-PEG2)-N-Fluorescein-PEG3-acid

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N-(Azido-PEG2)-N-Fluorescein-PEG3-acid Basic information
Product Name:N-(Azido-PEG2)-N-Fluorescein-PEG3-acid
Synonyms:N-(Azido-PEG2)-N-Fluorescein-PEG3-acid;PUN 89043;PROTAC Linker
CAS:2086689-04-3
MF:C36H41N5O12S
MW:767.81
EINECS:
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Mol File:2086689-04-3.mol
N-(Azido-PEG2)-N-Fluorescein-PEG3-acid Structure
N-(Azido-PEG2)-N-Fluorescein-PEG3-acid Chemical Properties
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MSDS Information
N-(Azido-PEG2)-N-Fluorescein-PEG3-acid Usage And Synthesis
DescriptionN-(Azido-PEG2)-N-Fluorescein-PEG3-acid is a fluorescein dye linker containing a terminal azide group and a terminal carboxylic acid. The azide group enables PEGylation via Click Chemistry. The terminal carboxylic acid can react with primary amino groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
UsesN-(Azido-PEG2)-N-Fluorescein-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG2)-N-Fluorescein-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
N-(Azido-PEG2)-N-Fluorescein-PEG3-acid Preparation Products And Raw materials
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