N-(Azido-PEG3)-N-Fluorescein-PEG4-acid

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N-(Azido-PEG3)-N-Fluorescein-PEG4-acid Basic information
Product Name:N-(Azido-PEG3)-N-Fluorescein-PEG4-acid
Synonyms:N-(Azido-PEG3)-N-Fluorescein-PEG4-acid
CAS:2100306-72-5
MF:C40H49N5O14S
MW:855.91
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Mol File:2100306-72-5.mol
N-(Azido-PEG3)-N-Fluorescein-PEG4-acid Structure
N-(Azido-PEG3)-N-Fluorescein-PEG4-acid Chemical Properties
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MSDS Information
N-(Azido-PEG3)-N-Fluorescein-PEG4-acid Usage And Synthesis
UsesN-(Azido-PEG3)-N-Fluorescein-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG3)-N-Fluorescein-PEG4-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Biological ActivityN-(Azido-PEG3)-N-Fluorescein-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50PEGs
References[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
N-(Azido-PEG3)-N-Fluorescein-PEG4-acid Preparation Products And Raw materials
Tag:N-(Azido-PEG3)-N-Fluorescein-PEG4-acid(2100306-72-5) Related Product Information
N-(Azido-PEG3)-N-Fluorescein-PEG3-acid Fluorescein-PEG4-Acid Fluorescein-PEG6-Acid 5-FITC-PEG3-azide N-(Azido-PEG2)-N-Fluorescein-PEG3-acid TCO-PEG4-NHS Ester