| Company Name: |
BOYAN PHARMA Gold |
| Tel: |
18566078841 18566078841 |
| Email: |
tanyan@boyanpharma.com |
Lefamulin acetate manufacturers
- Lefamulin Acetat
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2026-09-18
- CAS:1350636-82-6
- Min. Order: 1g
- Purity: More Than 99%
- Supply Ability: 100kg/Month
- Lefamulin Acetat.
-
-
2026-09-18
- CAS:1350636-82-6
- Min. Order: 1g
- Purity: More Than 99%
- Supply Ability: 100kg/Month
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| | Lefamulin acetate Basic information |
| Product Name: | Lefamulin acetate | | Synonyms: | BC-3781;BC 3781;BC3781;Lefamulin acetate;BC-3781 ACETATE;Lefamulin acetate (BC-3781 acetate);WSMXIQXWHPSVDE-WHAUHWDVSA-N USP/EP/BP;Inhibitor,Lefamulin,BC 3781,BC3781,Lefamulin acetate,inhibit,BC-3781,Bacterial,Antibiotic;Lefamulin acetate (Xenleta);Lefamulin Acetat | | CAS: | 1350636-82-6 | | MF: | C28H45NO5S.C2H4O2 | | MW: | 567.78 | | EINECS: | 208-388-5 | | Product Categories: | | | Mol File: | 1350636-82-6.mol |  |
| | Lefamulin acetate Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO:100.0(Max Conc. mg/mL);176.12(Max Conc. mM) | | form | Solid | | color | White to off-white | | InChIKey | WSMXIQXWHPSVDE-IHBHSJRLNA-N | | SMILES | C(=O)(O)C.C[C@H]1[C@@H]([C@](C[C@@H](OC(=O)CS[C@@H]2CC[C@@H](N)C[C@H]2O)C2([C@H](C)CCC31CCC(=O)[C@]32[H])C)(C)C=C)O |&1:5,6,7,9,15,18,21,24,33,r| |
| | Lefamulin acetate Usage And Synthesis |
| Chemical Properties |
Lefamulin acetate is a white to off-white solid. It is a stable compound (requiring no special storage conditions) which is highly soluble in water and 0.9% sodium chloride solution (>300mg/ml). The hydration level of lefamulin acetate at ambient conditions is typically below 1% w/w.
| | Uses |
Lefamulin (BC-3781) acetate is an orally active antibiotic. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin acetate has anti-inflammatory activity. Lefamulin acetate can be used in the research of bacterial infections, such as bacterial pneumonia.
| | Definition |
Lefamulin acetate is a single stereoisomer semi-synthetically derived from pleuromutilin, a homochiral, natural fermentation product of known absolute stereochemistry. Lefamulin acetate is a diastereomer with R-configuration at carbons of the cyclohexane moiety. The absolute configuration of the active substance has been confirmed by single-crystal structure determination.
| | Antimicrobial activity | Lefamulin acetate has activity against Gram-positive bacteria including MRSA, and atypical bacteria, especially those causing CAPB (i.e. Streptococcus pneumonia, Haemophilus influenzae, Mycoplasma pneumoniae, Legionella pneumophila, Chlamydophila pneumoniae). It also has activity against Gram-negative organisms. | | in vivo | Lefamulin (10-140 mg/kg, s.c.) acetate shows anti-inflammatory effect on LPS-induced lung neutrophilia mouse model[4].
Lefamulin (1.25-160 mg/kg, s.c.) acetate shows antibacterial effect in S. pneumoniae or S. aureus challenged lung infection mice[5].
| Animal Model: | LPS-induced lung neutrophilia mouse model[4] | | Dosage: | 10-140 mg/kg | | Administration: | Subcutaneous injection (s.c.) | | Result: | Reduced BALF neutrophil cell counts.
Reduced pro-inflammatory cytokine (TNF-α, IL-6, IL-1β, and GM-CSF), chemokine (CXCL-1, CXCL-2, and CCL-2) and MMP-9 levels in mouse lung tissue.
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| | Lefamulin acetate Preparation Products And Raw materials |
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