宾达氮芥
| 中文名称 | 宾达氮芥 |
|---|---|
| 中文同义词 | 宾达氮芥;苯达莫司汀;4-[5-[双(2-氯乙基)氨基]-1-甲基苯并咪唑-2-基]丁酸;盐酸苯达莫司汀/4-[5-[双(2-氯乙基)氨基]-1-甲基苯并咪唑-2-基]丁酸;4-(5-(双(2-氯乙基)氨基)-1-甲基-1H-苯并[D]咪唑-2-基)丁酸;宾达氮芥,10 MM DMSO 溶液;Bendamustine (SDX105) 苯达莫司汀,S5939;Bendamustine (SDX105) 苯达莫司汀，S5939 |
| 英文名称 | Bendamustine |
| 英文同义词 | 5-(Bis(2-chloroethyl)amino)-1-methyl-2-benzimidazolebutyric acid;5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid;Bendamustine;-1-methyl-1H-benzo[d]imidazol-2-yl);4-(5-(Bis(2-chloroethyl);4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid;4-(5-(bis(2-chloroethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoic acid;1H-BenziMidazole-2-butanoicacid, 5-[bis(2-chloroethyl)aMino]-1-Methyl- |
| CAS号 | 16506-27-7 |
| 分子式 | C16H21Cl2N3O2 |
| 分子量 | 358.26 |
| EINECS号 | |
| 相关类别 | 杂环类;化工 |
| Mol文件 | 16506-27-7.mol |
| 结构式 |  |
宾达氮芥 性质
| 沸点 | 585.2±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.31±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C, protect from light |
| 溶解度 | DMSO：100 mg/mL（279.13 mM；需要超声波） |
| 形态 | 固体 |
| 酸度系数(pKa) | 4.50±0.10(Predicted) |
| 颜色 | 白色至米白色 |
| InChI | InChI=1S/C16H21Cl2N3O2/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23/h5-6,11H,2-4,7-10H2,1H3,(H,22,23) |
| InChIKey | YTKUWDBFDASYHO-UHFFFAOYSA-N |
| SMILES | C1(CCCC(O)=O)N(C)C2=CC=C(N(CCCl)CCCl)C=C2N=1 |
DNA Alkylator/Crosslinker
Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties. Bendamustine uniquely regulates apoptosis pathways and DNA repair pathways in non-Hodgkin's lymphoma cells. Bendamustine (50 μM) induces p21 (Cip1/Waf1) and NOXA genes, and increases the expression of p53 in SU-DHL-1 cells. Bendamustine (25 μM) blocks mitotic checkpoints and cuases mitotic catastrophe.
Bendamustine reduces the viability of multiple myeloma (MM) cell lines, such as RPMI-8226 and 8226-LR5 cells, with IC
25
s of 101.8 μM and 585.5 μM after 24 h incubation, and 51.7 and 374.3 μM after 48 h incubation, respectively. Bendamustine induces a specific caspase-dependent MM cell death and inhibits the spindle-assembly checkpoint.
Bendamustine (25 mg/kg, i.v.) shows potent inhibition on the growth of tumor cells by 91%, 99% and 95% for DoHH-2, Granta 519 and RAMOS models, respectively. Moreover, the antitumor effect of Bendamustine is enhanced by rituximab in DoHH-2 and RAMOS models, but not in Granta 519 model.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/03/03 | S5939 | 宾达氮芥 Bendamustine | 16506-27-7 | 5mg | 959.1元 |
| 2026/03/03 | S5939 | 宾达氮芥 Bendamustine (SDX105) | 16506-27-7 | 10mM (1mL in DMSO) | 1122.03元 |