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| | RDNYSJATGQDZQN-DXBWTPJFSA-N Basic information |
| Product Name: | RDNYSJATGQDZQN-DXBWTPJFSA-N | | Synonyms: | RDNYSJATGQDZQN-DXBWTPJFSA-N;tert-butyl (S)-2-((1R,2R)-1-methoxy-3-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 2-[(1R,2R)-1-methoxy-3-[[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]-2-methyl-3-oxopropyl]-, 1,1-dimethylethyl ester, (2S)-; (S)-tert-butyl 2-((1R,2R)-1-methoxy-3-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate;tert-Butyl (S)-2-((1R,2R)-1-methoxy-3-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-2-methyl-3-ox;N-Boc-Dap-Phe-OMe;tert-butyl (S)-2-((1R,2R)-1-methoxy-3-(((R)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate;MMAF intermediate 1 | | CAS: | 161485-82-1 | | MF: | C24H36N2O6 | | MW: | 448.55 | | EINECS: | | | Product Categories: | | | Mol File: | 161485-82-1.mol |  |
| | RDNYSJATGQDZQN-DXBWTPJFSA-N Chemical Properties |
| Boiling point | 582.891±45.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.135±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 13.893±0.46(predicted) | | form | Solid | | color | White to off-white |
| | RDNYSJATGQDZQN-DXBWTPJFSA-N Usage And Synthesis |
| Uses | MMAF intermediate 1 is an intermediate in the synthesis of MMAF (HY-15579). MMAF (Monomethylauristatin F) is a potent inhibitor of tubulin polymerization and the cytotoxic (ADC Cytotoxin) component of classic antibody drug conjugates (ADCs), such as Vorsetuzumab mafodotin and SGN-CD19A[1]. | | References | [1] Lee JW, et al. EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma. Clin Cancer Res. 2010 May 1;16(9):2562-70. [Content Brief] DOI:10.1158/1078-0432.CCR-10-0017 |
| | RDNYSJATGQDZQN-DXBWTPJFSA-N Preparation Products And Raw materials |
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