3-[BENZYL-(2-METHOXYCARBONYL-ETHYL)-AMINO]-PROPIONIC ACID METHYL ESTER

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3-[BENZYL-(2-METHOXYCARBONYL-ETHYL)-AMINO]-PROPIONIC ACID METHYL ESTER Basic information
Synthesis
Product Name:3-[BENZYL-(2-METHOXYCARBONYL-ETHYL)-AMINO]-PROPIONIC ACID METHYL ESTER
Synonyms:3-[BENZYL-(2-METHOXYCARBONYL-ETHYL)-AMINO]-PROPIONIC ACID METHYL ESTER;methyl N-benzyl-N-(3-methoxy-3-oxopropyl)-beta-alaninate;N,N-BIS(B-(METHOXYCARBONYL)ETHYL)BENZYLAMINE;3,3'-(Benzylimino)bis(propionic acid methyl) ester;3,3'-(Benzylimino)bispropionic acid dimethyl ester;3,3'-(Benzylimino)dipropionic acid dimethyl ester;3,3'-Benzyliminobis(propanoic acid methyl) ester;N-(3-Methoxy-3-oxopropyl)-N-phenylmethyl-β-alanine methyl ester
CAS:793-19-1
MF:C15H21NO4
MW:279.34
EINECS:212-343-5
Product Categories:
Mol File:793-19-1.mol
3-[BENZYL-(2-METHOXYCARBONYL-ETHYL)-AMINO]-PROPIONIC ACID METHYL ESTER Structure
3-[BENZYL-(2-METHOXYCARBONYL-ETHYL)-AMINO]-PROPIONIC ACID METHYL ESTER Chemical Properties
Boiling point 150-161 °C(Press: 0.6 Torr)
density 1.108±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pka5.79±0.50(Predicted)
form Oil
color Colourless to Pale Yellow
Safety Information
MSDS Information
3-[BENZYL-(2-METHOXYCARBONYL-ETHYL)-AMINO]-PROPIONIC ACID METHYL ESTER Usage And Synthesis
SynthesisA neat mixture of methyl acrylate 129 (63 ml, 0.70 mol) and BnNH2 130 (25 g, 0.23 mol) was refluxed in the presence of Et3N (65 ml, 0.46 mol) overnight. Excess methyl acrylate was distilled off, the residue was taken in EtOAc and washed with water, brine, dried over anhydrous Na2SO4 and filtered. Solvent removed under reduced pressure. The resultant oil was chromatographed over silica gel using EtOAc-pet ether to furnish Michael adduct 131 as a yellow oil (58.67 g).
synthesis of dimethyl 3,3'-(benzylazanediyl)dipropionate

Uses3-[Benzyl-(2-methoxycarbonylethyl)amino]propionic Acid Methyl Ester is used in preparation of substituted Phenyloxazolidinones as antimicrobial agents for treating antimicrobial.
References[1] Patent: WO2017/15106, 2017, A1. Location in patent: Page/Page column 30
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 2013, vol. 56, # 14, p. 722 - 725
[3] Planta Medica, 2017, vol. 83, # 5, p. 420 - 425
[4] Patent: US2017/274362, 2017, A1. Location in patent: Paragraph 0077-0079
[5] Patent: EP2570410, 2013, A1. Location in patent: Paragraph 0062
3-[BENZYL-(2-METHOXYCARBONYL-ETHYL)-AMINO]-PROPIONIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materialsacrylic acid methyl ester-->Benzylamine
Preparation Products(Z)-tert-Butyl 2,3,6,7-tetrahydroazepine-1-carboxylate-->Methyl 1-Benzyl-4-hydroxypiperidine-3-carboxylate-->1-Benzyl-4-piperidone
Tag:3-[BENZYL-(2-METHOXYCARBONYL-ETHYL)-AMINO]-PROPIONIC ACID METHYL ESTER(793-19-1) Related Product Information
N-BENZYL-N-BIS(TERT-BUTYLPROPIONATE) AMINE trans-Dimethyl 1-benzyl-3,4-pyrrolidinedicarboxylate N-(2-CARBETHOXYETHYL)-N-(2-CARBOMETHOXYPROPYL)BENZYLAMINE cis-Dimethyl 1-benzyl-3,4-pyrrolidinedicarboxylate 3-[BENZYL-(2-ETHOXYCARBONYL-ETHYL)-AMINO]-PROPIONIC ACID ETHYL ESTER DIETHYL CIS-1-BENZYL-3,4-PYRROLIDINEDICARBOXYLATE 3-[BENZYL-(2-METHOXYCARBONYL-ETHYL)-AMINO]-PROPIONIC ACID METHYL ESTER