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1-Benzoyl-3-phenyl-2-thiourea manufacturers
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| | 1-Benzoyl-3-phenyl-2-thiourea Basic information |
| Product Name: | 1-Benzoyl-3-phenyl-2-thiourea | | Synonyms: | N-[anilino(sulfanylidene)methyl]benzamide;1-benzoyl-3-phenyl-2-thio-ure;n-phenylthiocarbamoyl-benzamid;phenylbenzoylthiourea;usafk-1473;1-Benzoyl-3-phenyl(thiourea);1-Benzoyl-3-phenylthiourea;N-(Phenylthiocarbamoyl)benzamide | | CAS: | 4921-82-8 | | MF: | C14H12N2OS | | MW: | 256.32 | | EINECS: | | | Product Categories: | | | Mol File: | 4921-82-8.mol |  |
| | 1-Benzoyl-3-phenyl-2-thiourea Chemical Properties |
| Melting point | 159 °C | | density | 1.290±0.06 g/cm3(Predicted) | | storage temp. | -20° | | solubility | Soluble in DMSO (greater than 50 mg/ml) or in Ethanol (up to 8 mg/ml). | | form | solid | | pka | 9.49±0.70(Predicted) | | color | Off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. | | CAS DataBase Reference | 4921-82-8(CAS DataBase Reference) |
| HazardClass | IRRITANT | | HS Code | 2930909899 |
| | 1-Benzoyl-3-phenyl-2-thiourea Usage And Synthesis |
| Description | TM-2-51 (4921-82-8) is a highly potent and isozyme selective activator of recombinant HDAC8. Increases the activity of HDAC8 by a factor of 12 at 10 μM. No activation of other HDACs is observed. TM-2-51 rescues the activity of catalytically compromised HDAC8 mutantsin vitro.2 | | References | [1] RAUSHAN K. SINGH . Histone deacetylase activators: N-acetylthioureas serve as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate[J]. Bioorganic & Medicinal Chemistry Letters, 2011, 21 19: Pages 5920-5923. DOI:10.1016/j.bmcl.2011.07.080
[2] CHRISTOPHE DECROOS. Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders[J]. ACS Chemical Biology, 2014, 9 9: 2157-2164. DOI:10.1021/cb5003762
[3] RAUSHAN K SINGH. Mechanism of N-Acylthiourea-mediated activation of human histone deacetylase 8 (HDAC8) at molecular and cellular levels.[J]. The Journal of Biological Chemistry, 2015, 290 10: 6607-6619. DOI:10.1074/jbc.m114.600627 |
| | 1-Benzoyl-3-phenyl-2-thiourea Preparation Products And Raw materials |
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