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4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline manufacturers
- PD 174265
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- $30.00
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2026-07-27
- CAS:216163-53-0
- Purity: 99.51%
- Supply Ability: 10g
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| | 4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline Basic information |
| Product Name: | 4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline | | Synonyms: | PD 174265;N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide;PD 174265 - CAS 216163-53-0 - Calbiochem;Propanamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-;N-(4-((3-Bromophenyl)amino)quinazolin-6-yl)propionamide;PD 174265, EGFR tyrosine kinase inhibitor;PD 174265, 10 mM in DMSO;4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline | | CAS: | 216163-53-0 | | MF: | C17H15BrN4O | | MW: | 371.23 | | EINECS: | | | Product Categories: | | | Mol File: | 216163-53-0.mol | ![4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline Structure](CAS/GIF/216163-53-0.gif) |
| | 4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline Chemical Properties |
| storage temp. | -20°C | | solubility | DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml | | form | Yellow solid | | color | Light yellow to yellow | | InChI | 1S/C17H15BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h3-10H,2H2,1H3,(H,21,23)(H,19,20,22) | | InChIKey | WUPUZEMRHDROEO-UHFFFAOYSA-N | | SMILES | Brc1cc(ccc1)Nc2ncnc3c2cc(cc3)NC(=O)CC |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | 4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline Usage And Synthesis |
| Description | PD 174265 is a potent, cell-permeable inhibitor of the tyrosine kinase activity of the epidermal growth factor (EGF) receptor (IC50 = 0.45 nM). It is effective in cells, blocking tyrosine phosphorylation induced by either EGF or heregulin (IC50s = 39 and 220 nM, respectively). The action of PD 174265 is reversible, which makes it a useful tool for comparative studies with irreversible inhibitors of EGFR kinase activity. | | Uses | PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR tyrosine kinase activity. | | General Description | A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 450 pM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033). | | Biochem/physiol Actions | Target IC50: 450 pM against EGF receptor (EGFR) tyrosine kinase activity | | Enzyme inhibitor | This substituted quinazoline (FWfree-base = 371.24 g/mol), also known as 4- [(3-bromophenyl)amino]-6-propionylamidoquinazoline, inhibits epidermal growth factor receptor (EGFR) protein-tyrosine kinase, IC50 = 0.45 nM. PD 174265 selectively targets and irreversibly inactivates the epidermal growth factor receptor tyrosine kinase through specific, covalent modification of a Cys-773. See also PD 168393 | | References | [1] D W FRY. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1998, 95 20: 12022-12027. DOI: 10.1073/pnas.95.20.12022 |
| | 4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline Preparation Products And Raw materials |
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