2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-ol

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2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-ol Basic information
Product Name:2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-ol
Synonyms:2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-ol;4(3H)-Pyrimidinone, 2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-;2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
CAS:65004-42-4
MF:C10H12N4O
MW:204.23
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Mol File:65004-42-4.mol
2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-ol Structure
2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-ol Chemical Properties
Melting point 135-137 °C
Boiling point 410.4±48.0 °C(Predicted)
density 1.30±0.1 g/cm3(Predicted)
pka7.42±0.50(Predicted)
Safety Information
MSDS Information
2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-ol Usage And Synthesis
UsesPyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 (DMT1), with a Ki of 20 μM (hDMT1). Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence with the extracellular pH. Pyrimidinone 8 can inhibit hDMT1-mediated iron uptake, with an IC50 of 13.8 μM[1].
References[1] Montalbetti N, et al. Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2. Biochem Pharmacol. 2015 Aug 1;96(3):216-24. DOI:10.1016/j.bcp.2015.05.002
2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-ol Preparation Products And Raw materials
Raw materials6-methyl-2-(nitroamino)-3,4-dihydropyrimidin-4-one-->2,4(1H,3H)-Pyrimidinedione, 6-methyl-, 2-hydrazone (9CI)-->Acetylacetone
Tag:2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-ol(65004-42-4) Related Product Information
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