DMT1 blocker 2 manufacturers
- DMT1 blocker 2
-
- $41.00
-
2026-08-08
- CAS:1062648-63-8
- Purity: 99.68%
- Supply Ability: 10g
- DMT1 blocker 2
-
- $41.00
-
2026-08-08
- CAS:1062648-63-8
- Purity: 99.68%
- Supply Ability: 10g
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| | DMT1 blocker 2 Basic information |
| Product Name: | DMT1 blocker 2 | | Synonyms: | DMT1 blocker 2;uptake,iron,metal,DMT1,transporter,divalent,DMT-1 blocker 2,DMT1 blocker 2,Inhibitor,inhibit,enterocytes,direct;2H-Benz[e]indazol-1-ol, 4,5-dihydro-2-(2-pyridinyl)-;2-(Pyridin-2-yl)-4,5-dihydro-2H-benzo[e]indazol-1-ol;DMT1 blocker 2, 10 mM in DMSO | | CAS: | 1062648-63-8 | | MF: | C16H13N3O | | MW: | 263.29 | | EINECS: | | | Product Categories: | | | Mol File: | 1062648-63-8.mol |  |
| | DMT1 blocker 2 Chemical Properties |
| Boiling point | 512.8±45.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 7.04±0.20(Predicted) | | color | White to yellow |
| | DMT1 blocker 2 Usage And Synthesis |
| Uses | DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo[1]. | | in vivo | DMT1 blocker 2 (50 mg/kg; p.o.) blocks iron uptake by enterocytes in an acute rat model of iron hyperabsorption[1]. | Animal Model: | Weanling (3-4 weeks) rats were placed on a low iron diet for four weeks[1] | | Dosage: | 50 mg/kg | | Administration: | Oral gavage followed 1 h later by an iron challenge | | Result: | Attenuated the post-challenge serum iron increase. |
| | References | [1] Cadieux JA, et, al. Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem Lett. 2012 Jan 1;22(1):90-5. DOI:10.1016/j.bmcl.2011.11.069 |
| | DMT1 blocker 2 Preparation Products And Raw materials |
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