15(R)-19(R)-Hydroxy prostaglandin E2

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Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774 400-920-5774
Email: sales@glpbio.cn
15(R)-19(R)-Hydroxy prostaglandin E2 Basic information
Product Name:15(R)-19(R)-Hydroxy prostaglandin E2
Synonyms:9-OXO-11ALPHA,15R,19R-TRIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID;WTJYDBMHYPQFNJ-JDIRIWFDSA-N;Prosta-5,13-dien-1-oic acid, 11,15,19-trihydroxy-9-oxo-, (5Z,11α,13E,15S,19S)- (9CI);15(R)-19(R)-Hydroxy prostaglandin E2
CAS:54142-29-9
MF:C20H32O6
MW:368.47
EINECS:
Product Categories:
Mol File:54142-29-9.mol
15(R)-19(R)-Hydroxy prostaglandin E2 Structure
15(R)-19(R)-Hydroxy prostaglandin E2 Chemical Properties
Boiling point 600.100±55.00 °C(Press: 760.00 Torr)(predicted)
density 1.209±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
solubility DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS (pH 7.2): 5 mg/ml (from PGE2)
pka4.754±0.10(predicted)
Safety Information
MSDS Information
15(R)-19(R)-Hydroxy prostaglandin E2 Usage And Synthesis
Description19(R)-Hydroxylated prostaglandins occur in μg/ml concentrations in the semen of certain mammalian species, especially primates. In the case of humans, the compounds are primarily of the PGE series, and the hydroxyl stereochemistry is 15(S),19(R).1 19(R)-Hydroxylated prostaglandins are also found in the seminal plasma of marsupials, where F-type compounds of the 1 and 2-series predominate.2 The 15(R)-hydroxy epimer of these 19-hydroxylated prostaglandins is the inverse or “unnatural” isomer at C-15. The biological role of 19(R)-hydroxylated prostaglandins is not well established. In the E-series, 19(R)-hydroxylation has been identified with EP2 receptor subtype selectivity.3
References1. Cooper, I., and Kelly, R.W. The measurement of E and 19-hydroxy E prostaglandins in human seminal plasma Prostaglandins 10(3),507-514(1975).
2. Marley, P.B., Rodger, J.C., White, I.G., et al. 19-Hydroxylated prostaglandins in the semen of the marsupial Trichosurus vulpecula (brush-tailed possum) Comp. Biochem. Physiol. B Biochem. Mol. Biol. 70(3),619-621(1981).
3. Woodward, D.F., Protzman, C.E., Krauss, A.H.P., et al. Identification of 19(R)-OH prostaglandin E2 as a selective prostanoid EP2-receptor agonist Prostaglandins 46(4),371-383(1993).
15(R)-19(R)-Hydroxy prostaglandin E2 Preparation Products And Raw materials
Tag:15(R)-19(R)-Hydroxy prostaglandin E2(54142-29-9) Related Product Information
15(R)-19(R)-Hydroxy prostaglandin E2 15(R)-PROSTAGLANDIN E2