2-Methyl-5-nitronicotinic acid manufacturers
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| | 2-Methyl-5-nitronicotinic acid Basic information |
| | 2-Methyl-5-nitronicotinic acid Chemical Properties |
| Melting point | 215-215.5 °C | | Boiling point | 370.1±42.0 °C(Predicted) | | density | 1.477±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 2.47±0.10(Predicted) | | Appearance | Light brown to brown Solid |
| Hazard Codes | Xi | | HazardClass | IRRITANT |
| | 2-Methyl-5-nitronicotinic acid Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2-methyl-5-nitronicotinic acid from ethyl 2-methyl-5-nitronicotinate: compound D4 (300 g, 1.4 mol) was dissolved in a mixture of 800 mL hydrochloric acid and 800 mL water. The reaction mixture was heated under reflux conditions for 1 hour. Upon completion of the reaction, it was cooled to room temperature, the reaction solution was diluted with 2.0 L of water and slowly neutralized with the addition of solid sodium bicarbonate to pH=5.0. During this process, a precipitate was gradually formed. The mixture was further cooled and the precipitate was collected by filtration. After drying, brown solid D5 (223 g, 85.7% yield) was obtained. The product was characterized by 1H NMR (DMSO-d6, 300 MHz): δ = 2.84 (s, 3H), 8.74-8.75 (d, 1H), 9.35-9.36 (d, 1H), 13.90 (s, 1H).LC-MS analysis showed that the [M-1]+ peak was located at 180.9. | | References | [1] Patent: WO2008/88881, 2008, A1. Location in patent: Page/Page column 33-34
[2] Journal of the American Chemical Society, 1953, vol. 75, p. 737
[3] Patent: WO2007/56016, 2007, A2. Location in patent: Page/Page column 105 |
| | 2-Methyl-5-nitronicotinic acid Preparation Products And Raw materials |
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