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| | Nociceptin (1-7) Basic information |
| Product Name: | Nociceptin (1-7) | | Synonyms: | Nociceptin Fragment 1-7;Orphanin FQ Fragment 1-7;L-Alanine, L-phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-;Nociceptin (1-7) (Orphanin FQ (1-7)), Endogenous ligand for ORL1;Nociceptin (1-7)、1-7-Orphanin FQ (pig);Nociceptin (1-7) | | CAS: | 178249-42-8 | | MF: | C31H41N7O9 | | MW: | 655.7 | | EINECS: | | | Product Categories: | Opioid receptor and opioid-like receptor | | Mol File: | Mol File |  |
| | Nociceptin (1-7) Chemical Properties |
| Boiling point | 1193.6±65.0 °C(Predicted) | | density | 1.319±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | form | Powder | | pka | 3.42±0.10(Predicted) | | Water Solubility | Soluble to 2 mg/ml in water | | Sequence | Phe-Gly-Gly-Phe-Thr-Gly-Ala |
| | Nociceptin (1-7) Usage And Synthesis |
| Uses | Nociceptin (1-7), also known as orphanin FQ, is identified as naturally occurring agonist of orphan opioid receptor-like ORL1 receptor. | | in vivo | Nociceptin (1-7) (intrathecal injection; 150–1200 nmol; single dose) has no significant effect in the nociceptive thermal threshold (hyperalgesia). However, when nociceptin (1–7) is injected simultaneously with nociceptin (3.0fmol), nociceptin-induced hyperalgesia is significantly reduced[1]. | Animal Model: | Mice[1] | | Dosage: | 150–1200 nmol | | Administration: | Intrathecal injection; single dose | | Result: | Co-treatment with nociceptin could reduce hyperalgesia. |
| | IC 50 | NOP Receptor/ORL1 |
| | Nociceptin (1-7) Preparation Products And Raw materials |
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