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| | JDTic (2HCl) Basic information |
| Product Name: | JDTic (2HCl) | | Synonyms: | JDTic (dihydrochloride);(R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)-3-methylbutan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide;JDTic (2HCl);(3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide hydrochloride;(R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)-3-methylbutan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride;CS-648;(3R)-7-hydroxy-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride;(3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide | | CAS: | 785835-79-2 | | MF: | C28H40ClN3O3 | | MW: | 502.1 | | EINECS: | | | Product Categories: | tetrahydroisoqu | | Mol File: | 785835-79-2.mol |  |
| | JDTic (2HCl) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Powder | | color | White to off-white |
| | JDTic (2HCl) Usage And Synthesis |
| Uses | JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception. | | Biological Activity | jdtic is a selective inhibitor of kappa opioid receptor with ic50 value of 0.02nm [1].jdtic is one of the kappa opioid receptor selective antagonists. these antagonists are thought as potential pharmacotherapies for addiction, anxiety disorders, depression, psychosis disorders and obesity. because of the unique structural feature of jdtic, it is more selective and potent for kor activity than other kor antagonists. jdtic is shown to block the antinociceptive response of nicotine in the tail-flick test with a dose-dependent manner. it (8 mg/kg) can also block the nicotine withdrawal signs in mice via effecting the expression of a cpa associated with nicotine withdrawal. additionally, jdtic is also reported to decrease the number of somatic withdrawal signs in morphine-dependent rats [2,3]. | | in vivo | JDTic (2.5-16 mg/kg, s.c.) dose-dependently blocks the antinociceptive response of nicotine in the tail-flick test but has no effect in the hot-plate assay or body temperature assessments at any dose tested in the mice injected with nicotine[1]. JDTic (3 mg/kg, i.p.) is capable of reversing anxiety-like behavior in the rat model of hangover anxiety. JDTic (10 mg/kg, i.p.) decreases alcohol self-administration, suppresses cue-induced reinstatement of alcohol seeking, and specifically blocks the effects of a KOR agonist at the 2 h pretreatment time point[2]. JDTic (30 mg/kg, i.g.) significantly blockes U50,488-induced diuresis immediately in rats[3]. | | target | kappa opioid receptor | | references | [1] michael p. hedrick, palak gosalia, kelin li, kevin frankowski, shenghua shi, thomas e. prisinzano, frank schoenen, jeffrey aubé, ying su, s. vasile, eduard sergienko, wilson gray, santosh hariharan, loribelle milan, susanne heynen-genel, bryan l. roth, jon evans, vincent setola, thomas d.y. chung, marc caron, laura m. bohn and lawrence s. barak. antagonist for the kappa opioid receptor. molecular libraries. 2011 jun: 1-32.
[2] scott p. runyon, lawrence e. brieaddy, s. wayne mascarella, james b. thomas, hernán a. navarro, james l. howard, gerald t. pollard, and f. ivy carroll. analogues of (3r)-7-hydroxy-n-[(1s)-1-{[(3r,4r)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide(jdtic). synthesis and in vitro and in vivo opioid receptor antagonist activity. j med chem. 2010 july, 53(14): 5290–5301.
[3] k. j. jackson, frank ivy carroll, s. s. negus and m. i. damaj. effect of the selective kappa-opioid receptor antagonist jdtic on nicotine antinociception, reward, and withdrawal in the mouse. psychopharmacology (berl). 2010 june, 210(2): 285–294. |
| | JDTic (2HCl) Preparation Products And Raw materials |
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