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BOC Sciences |
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16314854226; +8616314854226 |
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inquiry@bocsci.com |
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| Product Name: | AUY954 | | Synonyms: | AUY954;β-Alanine, N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-;AUY-954 free base;AUY 954 free base,AUY954 free base;N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-β-alanine;3-[[2-[4-Phenyl-3-(trifluoromethyl)phenyl]-1-benzothiophen-5-yl]methylamino]propanoic acid | | CAS: | 820240-77-5 | | MF: | C25H20F3NO2S | | MW: | 455.49 | | EINECS: | | | Product Categories: | | | Mol File: | 820240-77-5.mol |  |
| | AUY954 Chemical Properties |
| Boiling point | 646.3±55.0 °C(Predicted) | | density | 1.314±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml | | form | A crystalline solid | | pka | 3.62±0.12(Predicted) |
| | AUY954 Usage And Synthesis |
| Description | AUY954 is an orally bioavailable and selective agonist of the sphingosine-1-phosphate receptor 1 (S1P1; EC50 = 1.2 nM for stimulating GTPγS binding to S1P1 in CHO cells). It is highly selective for the S1P1 receptor with EC50 values of >10,000, 1,210, >1,000, and 340 nM for S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 reduces circulating lymphocytes and prevents rejection of rat heart allografts. In a rat model of experimental autoimmune neuritis, chronic treatment with AUY954 (10 mg/kg), starting on the day of immunization, almost completely prevents peripheral paralysis. In the same model, it also decreases T cell, B cell, and macrophage infiltration and perivascular demyelination in sciatic nerves. | | Uses | AUY954 is an oral active and selective sphingosine-1-phosphate receptor 1 agonist with the EC50 values of 1.2 nM, 0.9 nM >10,000 nM, 1,210 nM, >1,000 nM, and 340 nM for hS1P2, mS1P2, S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 can be used for study of experimental autoimmune neuritis[1][2]. | | References | [1] Pan S,et al. A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol. 2006;13(11):1227-1234. DOI:10.1016/j.chembiol.2006.09.017
[2] Zhang ZY, et al. AUY954, a selective S1P(1) modulator, prevents experimental autoimmune neuritis. J Neuroimmunol. 2009;216(1-2):59-65. DOI:10.1016/j.jneuroim.2009.09.010 |
| | AUY954 Preparation Products And Raw materials |
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