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BOC Sciences |
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PF-06860932 manufacturers
- CFTR corrector 6
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- $476.00
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2026-07-15
- CAS:2226970-01-8
- Purity:
- Supply Ability: 10g
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| | PF-06860932 Basic information |
| Product Name: | PF-06860932 | | Synonyms: | PF-06860932;CFTR corrector 6;7H-Pyrrolo[2,3-d]pyrimidine-6-carbonitrile, 4-amino-7-[[1-(2-fluorophenyl)-1H-pyrazol-4-yl]methyl]-5-[2-(trifluoromethyl)-5-pyrimidinyl]-;4-amino-7-{[1-(2-fluorophenyl)pyrazol-4-yl]methyl}-5-[2-(trifluoromethyl)pyrimidin-5-yl]pyrrolo[2,3-d]pyrimidine-6-carbonitrile - [AC78157] | | CAS: | 2226970-01-8 | | MF: | C22H13F4N9 | | MW: | 479.39 | | EINECS: | | | Product Categories: | | | Mol File: | 2226970-01-8.mol |  |
| | PF-06860932 Chemical Properties |
| Boiling point | 697.4±55.0 °C(Predicted) | | density | 1.60±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 3.23±0.30(Predicted) | | form | Solid | | color | White to off-white |
| | PF-06860932 Usage And Synthesis |
| Uses | CFTR corrector 6 is a potent potentiator of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR corrector 6 has the potential for cystic fibrosis (CF) and other CFTR associated disorders research[1]. | | Biological Activity | CFTR corrector 6 is a potent potentiator of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR corrector 6 has the potential for cystic fibrosis (CF) and other CFTR associated disorders research[1].
CFTR corrector 6 (Example 27) has EC50s of 1.25 nM and 1.27 nM for primary cystic fibrosis human bronchial epithelial (CF hBE) cells and fischer rat thyroid (FRT) cell lines[1]. | | References | [1]. Joseph Walter Strohbach, et al. Pyrrolopyrimidines as cftr potentiators. WO2018094137A1 |
| | PF-06860932 Preparation Products And Raw materials |
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