Umibecestat manufacturers
- Umibecestat
-
- $175.00
-
2026-07-27
- CAS:1387560-01-1
- Purity: 99.88%
- Supply Ability: 10g
- Umibecestat
-
- $175.00
-
2026-07-27
- CAS:1387560-01-1
- Purity: 99.88%
- Supply Ability: 10g
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| | Umibecestat Basic information |
| Product Name: | Umibecestat | | Synonyms: | Umibecestat;Umibecestat(CNP520);BACE,Beta-secretase,inhibit,CNP-520,β-Secretase,CNP 520,Inhibitor;2-Pyridinecarboxamide, N-[6-[(3R,6R)-5-amino-3,6-dihydro-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-5-fluoro-2-pyridinyl]-3-chloro-5-(trifluoromethyl)-;N-{6-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-5-fluoropyridin-2-yl}-3-chloro-5-(trifluoromethyl)pyridine-2-carboxamide;Umibecestat, 10 mM in DMSO;N-(6-((3R,6R)-5-Amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-5-fluoropyridin-2-yl)-3-chloro-5-(trifluoromethyl)picolinamide | | CAS: | 1387560-01-1 | | MF: | C19H15ClF7N5O2 | | MW: | 513.8 | | EINECS: | | | Product Categories: | | | Mol File: | 1387560-01-1.mol |  |
| | Umibecestat Chemical Properties |
| density | 1.59±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 100 mg/mL (194.63 mM; Need ultrasonic) | | pka | 8.67±0.70(Predicted) | | form | Solid | | color | White to off-white |
| | Umibecestat Usage And Synthesis |
| Uses | Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively[1]. Umibecestat can be used for the research of alzheimer's disease. | | in vivo | Umibecestat (CNP520) (1.5-51.3 mg/kg; given by oral gavage; 72 hours) shows a dose-dependent effects on Aβ40 and a long duration of action in both rat brain and CSF[1].
Umibecestat (CNP520) (3.1 mg/kg; oral administration; 7 days) shows a > 75% reduction on Aβ40 and Aβ42 in CSF after dosing and returns slowly to baseline over the next 7 days[1]. | Animal Model: | Male rats (3-4 months old)[1] | | Dosage: | 1.5 mg/kg (3 μM/kg)-51.3 mg/kg (100 μM/kg) | | Administration: | Given by oral gavage; 72 hours | | Result: | Reduced 89.3±4.5% Aβ40 at the highest dose in brain tissue, and 50% lowering of rat brain Aβ40 (ED50) was 2.4±0.31 mg/kg. Reduced ~50% Aβ40 at a single oral 30 μM/kg (15.4 mg/kg) dose after 24 hours in both rat brain and CSF。 |
| Animal Model: | 3-month-old beagle dogs[1] | | Dosage: | 3.1 mg/kg (6 μM/kg) | | Administration: | Oral administration; 7 days | | Result: | Both Aβ40 and Aβ42 concentrations in CSF showed a > 75% reduction at 12-48 h after dosing and returned slowly to baseline over the next 7 days. |
| | References | [1] Neumann U, et al. The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease. EMBO Mol Med. 2018 Nov;10(11). pii: e9316. DOI:10.15252/emmm.201809316 |
| | Umibecestat Preparation Products And Raw materials |
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