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| | Handle region peptide (HRP),rat Basic information |
| Product Name: | Handle region peptide (HRP),rat | | Synonyms: | Handle region peptide (HRP),rat;Handle region peptide, rat;L-Valine, L-arginyl-L-isoleucyl-L-leucyl-L-leucyl-L-lysyl-L-lysyl-L-methionyl-L-prolyl-L-seryl-;(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-6-amino-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-[(2S)-2-amino-5-[(diaminomethylidene)amino]pentanamido]-3-methylpentanamido]-4-methylpentanamido]-4-methylpentanamido]hexanamido]hexanamido]-4-(methylsulfanyl)butanoyl]pyrrolidin-2-yl]formamido}-3-hydroxypropanamido]-3-methylbutanoic acid | | CAS: | 749227-53-0 | | MF: | C54H101N15O12S | | MW: | 1184.54 | | EINECS: | | | Product Categories: | | | Mol File: | 749227-53-0.mol |  |
| | Handle region peptide (HRP),rat Chemical Properties |
| density | 1.34±0.1 g/cm3(Predicted) | | pka | 3.27±0.10(Predicted) |
| | Handle region peptide (HRP),rat Usage And Synthesis |
| Uses | Handle region peptide, rat is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye. | | in vivo | Handle region peptide, rat (0.1 mg/kg) suppresses leukocyte adhesion in the endotoxin-induced uveitis (EIU) retina, and decreases the leukocyte counts in rats. Handle region peptide, rat (0.1 mg/kg) lowers the protein concentration in EIU rats induced by LPS, and reduces the mRNA expression and the protein levels of inflammatory mediators such as ICAM-1, CCL2/MCP-1, and IL-6 in rats[2]. | | References | [1] He M, et al. Inhibition of renin/prorenin receptor attenuated mesangial cell proliferation and reduced associated fibrotic factor release. Eur J Pharmacol. 2009 Mar 15;606(1-3):155-61. DOI:10.1016/j.ejphar.2008.12.050
[2] Satofuka S, et al. Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2686-92. DOI:10.1167/iovs.05-1458 |
| | Handle region peptide (HRP),rat Preparation Products And Raw materials |
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