Tat-Beclin 1 Peptide

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Tat-Beclin 1 Peptide Basic information
Product Name:Tat-Beclin 1 Peptide
Synonyms:Tat-Beclin 1 Peptide;Tat-beclin 1 (Tat-BECN1)
CAS:1423821-88-8
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
Tat-Beclin 1 Peptide Structure
Tat-Beclin 1 Peptide Chemical Properties
storage temp. -20°C
form Solid
color White to off-white
Water Solubility Water : 25 mg/mL (6.68 mM; Need ultrasonic)
SequenceTyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
Tat-Beclin 1 Peptide Usage And Synthesis
UsesTat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV)[1].
General DescriptionThe TAT-BECLIN-1 (autophagy activator) peptide is derived from a region of the autophagy protein, beclin 1, attached to the HIV-1 Tat protein transduction domain. The peptide includes 11 amino acids at the N terminus derived from the Tat protein transduction domain, 18 amino acids (267–284 aa) from beclin 1 at the C terminus and a GG linker.
Biochem/physiol ActionsThe TAT-BECLIN-1 (autophagy activator) peptide reduces the accumulation of polyglutamine aggregates and pathogen replication in vitro. This peptide is also found to reduce the mortality of mice infected by different viruses. The TAT-BECLIN-1 peptide is predicted to stimulate cell death via autophagy.
in vivo

Tat-beclin 1 (15 mg/kg; i.p.; daily; beginning 1 day post-infection for 20 days) can induce autophagy in peripheral tissues in adult mice as well as in the central nervous system of neonatal mice (6-week-old GFP-LC3 mice)[1].

IC 50HIV-1
References[1] Sanae Shoji-Kawata, et al. Identification of a Candidate Therapeutic Autophagy-Inducing Peptide. Nature. 2013 Feb 14;494(7436):201-6. DOI:10.1038/nature11866
Tat-Beclin 1 Peptide Preparation Products And Raw materials
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