H-TYR-GLY-PHE-GLY-GLY-OH manufacturers
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| | H-TYR-GLY-PHE-GLY-GLY-OH Basic information |
| Product Name: | H-TYR-GLY-PHE-GLY-GLY-OH | | Synonyms: | OGP (10-14);H-TYR-GLY-PHE-GLY-GLY-OH;historphin;Glycine, N-(N-(N-(N-L-tyrosylglycyl)-L-phenylalanyl)glycyl)-;Tyr-Gly-Phe-Gly-gly;Tyrosyl-glycyl-phenylalanyl-glycyl-glycine;Glycine, L-tyrosylglycyl-L-phenylalanylglycyl-;osteogénico (OGP10-14, YGFGG) | | CAS: | 105250-85-9 | | MF: | C24H29N5O7 | | MW: | 499.52 | | EINECS: | | | Product Categories: | | | Mol File: | 105250-85-9.mol |  |
| | H-TYR-GLY-PHE-GLY-GLY-OH Chemical Properties |
| Boiling point | 1028.0±65.0 °C(Predicted) | | density | 1.352±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 3.32±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | H-TYR-GLY-PHE-GLY-GLY-OH Usage And Synthesis |
| Uses | Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor[1][2][3][4]. | | in vivo | Osteogenic Growth Peptide (10-14) (OGP(10-14)) increases bone formation and trabecular bone density and stimulates fracture healing when administered to mice and rats[1]. | | References | [1] Chen YC, et al. Bioactive pseudopeptidic analogues and cyclostereoisomers of osteogenic growth peptide C-terminal pentapeptide, OGP(10-14). J Med Chem. 2002;45(8):1624-1632. DOI:10.1021/jm010479l
[2] Chen Z, et al. Regulation of endochondral ossification by osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)]. Protein Pept Lett. 2009;16(9):1074-1080. DOI:10.2174/092986609789055395
[3] Fazzi R, et al. Bone and bone-marrow interactions: haematological activity of osteoblastic growth peptide (OGP)-derived carboxy-terminal pentapeptide. Mobilizing properties on white blood cells and peripheral blood stem cells in mice. Leuk Res. 2002;26(1) DOI:10.1016/s0145-2126(01)00091-1
[4] Battolla B, et al. The small peptide OGP(10-14) reduces proliferation and induces differentiation of TPO-primed M07-e cells through RhoA/TGFbeta1/SFK pathway. Med Sci Monit. 2011;17(1):SC1-SC5. DOI:10.12659/msm.881309 |
| | H-TYR-GLY-PHE-GLY-GLY-OH Preparation Products And Raw materials |
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