| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
CP-24879 hydrochloride manufacturers
|
| | CP-24879 hydrochloride Basic information |
| Product Name: | CP-24879 hydrochloride | | Synonyms: | 4-(3-METHYLBUTOXY)-BENZENAMINE HYDROCHLORIDE;p-isopentoxyaniline;P-ISOPENTOXYANILINE HYDROCHLORIDE;P-(ISOPENTYLOXY)-ANILINE HYDROCHLORIDE;Benzenamine, 4-(3-methylbutoxy)-;a€￠ Benzenamine, 4-(3-methylbutoxy)-;CP-24879;CP-24879 hydrochloride >=98% (HPLC), powder | | CAS: | 10141-51-2 | | MF: | C11H18ClNO | | MW: | 215.72 | | EINECS: | | | Product Categories: | | | Mol File: | 10141-51-2.mol |  |
| | CP-24879 hydrochloride Chemical Properties |
| Melting point | 154-159 °C | | storage temp. | room temp | | solubility | DMSO: 22 mg/mL | | form | solid | | color | off-white | | InChI | 1S/C11H17NO.ClH/c1-9(2)7-8-13-11-5-3-10(12)4-6-11;/h3-6,9H,7-8,12H2,1-2H3;1H | | InChIKey | GFESZSNFRSACMU-UHFFFAOYSA-N | | SMILES | Cl[H].CC(C)CCOc1ccc(N)cc1 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | CP-24879 hydrochloride Usage And Synthesis |
| Uses | CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research[1][2]. | | Biochem/physiol Actions | delta5/delta6 (Δ5/Δ6) desaturase inhibitor. | | in vivo | CP-24879 (hydrochloride) (3 mg/kg, IP, three times a day, for 6 or 4 days) inhibits Δ6 + Δ5 desaturase activities in vivo, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice[1].
CP-24879 (hydrochloride) (33 mg/kg, IV, once) is cleared quite rapidly and has a relatively short half-life[1]. | Animal Model: | Chow-fed and EFAD Balb/C mice (N = 5/group) [1] | | Dosage: | 3 mg/kg | | Administration: | IP, three times a day, for 6 or 4 days | | Result: | Inhibited approximately 80% combined Δ6 + Δ5 desaturase activities, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice, and increased OA and LA, with a higher ratio of LA/AA in the livers of mice injected with CP-24879 versus saline (4.70 vs 2.00, Chow-fed mice; 2.46 vs 1.40, EFAD mice; respectively). |
| Animal Model: | Swiss-Webster mice (male, 25 g) [1] | | Dosage: | 33 mg/kg | | Administration: | IV in the tail vein, once (Pharmacokinetic Analysis) | | Result: | Was readily distributed to the peripheral tissues, with the volume of distribution (V) of 1.9 mL/g, was cleared quite rapidly (CL = 0.56 mL/min) and had a relatively short half-life (T1/2 = 59 min). |
| | References | [1] Obukowicz MG, et al. Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. Biochem Pharmacol. 1998 Apr 1;55(7):1045-58. DOI:10.1016/s0006-2952(97)00665-5
[2] [2]López-Vicario C, et al. Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis. Gut. 2014 Feb;63(2):344-55. DOI:10.1136/gutjnl-2012-303179
[3] [3]Lee JY, Nam M, Son HY, et al. Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer. Proc Natl Acad Sci U S A. 2020;117(51):32433-32442. DOI:10.1073/pnas.2006828117 |
| | CP-24879 hydrochloride Preparation Products And Raw materials |
|