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| | HUMAN IL-1 SRII Basic information |
| Product Name: | HUMAN IL-1 SRII | | Synonyms: | INTERLEUKIN-1 SOLUBLE RECEPTOR TYPE II;HUMAN INTERLEUKIN 1 RECEPTOR TYPE II EXTRACELLULAR DOMAIN;HUMAN IL-1 SRII;Interleukin-1β from rat;hIL-1α.;IL-1;IL-I sRII;Interleukin-1 Soluble Receptor, Type II human | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![HUMAN IL-1 SRII Structure]() |
| | HUMAN IL-1 SRII Chemical Properties |
| storage temp. | −20°C | | form | lyophilized powder | | biological source | rat |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | HUMAN IL-1 SRII Usage And Synthesis |
| Uses | Interleukin-1α (IL-1α) has been used:
- to study its effects on human colorectal adenocarcinoma cells
- to stimulate primary human fetal retinal pigment epithelium (hfRPE) cells
- to pre-stimulate human THP-1 monocytes
| | General Description | Interleukin-1 (IL-1), originally known as Lymphocyte Activating Factor (LAF), activates T cells and lymphocytes, which then proliferate and secrete interleukin-2.1 IL-1 is primarily released from stimulated macrophages and monocytes, but is also released from several other cell types,2 and is thought to play a key role in inflammatory and immune responses.3 Other synonyms for IL-1 include: Endogenous Pyrogen (EP), Mitogenic Protein (MP), Helper Peak-1 (HP-1), T Cell Replacing Factor III (TRF III or TRFH), B cell Activating Factor (BAF) and B Cell Differentiation Factor (BDF).4 The two closely related agents, Interleukin-1α (IL-1α) and Interleukin-1β (IL-1β) bind to the same cell surface receptor, elicit nearly identical biological responses and yet share 25% homology in their amino acid sequence. Recombinant rat IL-1β is a 17.3 kDa protein containing 153 amino acid residues. | | Biological Activity | Interleukin-1α (IL-1α) plays a crucial role in inflammation during cell necrosis. It also regulates the recruitment of interleukin-1β (IL-1β), neutrophils, chemokines, and other cytokines at the site of injury. IL-1α exhibits a dual function of binding to its cell surface receptor as well as chromatin. |
| | HUMAN IL-1 SRII Preparation Products And Raw materials |
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