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ARN19874 manufacturers
- ARN19874
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- $997.00
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2026-04-22
- CAS:2190502-57-7
- Purity:
- Supply Ability: 10g
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| | ARN19874 Basic information |
| Product Name: | ARN19874 | | Synonyms: | ARN19874;ARN19874
(ARN-19874);6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-2,4-dioxo-N-[4-(4-pyridinyl)phenyl]-;1,2,3,4-tetrahydro-2,4-dioxo-N-[4-(4-pyridinyl)phenyl]-6-quinazolinesulfonamide | | CAS: | 2190502-57-7 | | MF: | C19H14N4O4S | | MW: | 394.4 | | EINECS: | | | Product Categories: | | | Mol File: | 2190502-57-7.mol |  |
| | ARN19874 Chemical Properties |
| density | 1.466±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 1 mg/ml | | form | A crystalline solid | | pka | 7.44±0.20(Predicted) | | color | Off-white to pink |
| | ARN19874 Usage And Synthesis |
| Description | ARN19874 is an inhibitor of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD; IC50 = 33.7 μM). It is selective for NAPD-PLD over carbonic anhydrase II, neutral endopeptidase, and angiotensin-converting enzyme (ACE) up to 50 μM. ARN19874 (50 μM) increases the levels of certain NAPE substrates and decreases the endogenous levels of stearoyl ethanolamide , but not oleoyl ethanolamide or palmitoyl ethanolamide , in HEK293 cells. | | Uses | ARN19874 is a selective, reversible uncompetitive N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) activity inhibitor with an IC50 of ~34 μM[1]. | | References | [1] Castellani B, et al. Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD). Chem Commun (Camb). 2017 Nov 28;53(95):12814-12817. DOI:10.1039/c7cc07582k |
| | ARN19874 Preparation Products And Raw materials |
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