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| | COX (ovine) Colorimetric Inhibitor Screening Assay Kit Basic information |
| | COX (ovine) Colorimetric Inhibitor Screening Assay Kit Chemical Properties |
| | COX (ovine) Colorimetric Inhibitor Screening Assay Kit Usage And Synthesis |
| Description | The COX Colorimetric Inhibitor Screening Assay measures the peroxidase component of cyclooxygenases. The peroxidase activity is assayed colorimetrically by monitoring the appearance of oxidized N,N,N'',N''-tetramethyl-p-phenylenediamine (TMPD) at 590 nm. Inhibition of COX activity, measured by TMPD oxidation, by a variety of selective and nonselective inhibitors, shows changed potencies similar to those observed with other in vitro methods. The COX Colorimetric Inhibitor Screening assay includes both ovine COX-1 and COX-2 enzymes in order to screen isozyme-specific inhibitors. The Cayman COX Colorimetric Assay is a time saving tool for screening vast numbers of inhibitors. | | References | [1] AFTAB AHMAD. Ursolic acid rich Ocimum sanctum L leaf extract loaded nanostructured lipid carriers ameliorate adjuvant induced arthritis in rats by inhibition of COX-1, COX-2, TNF-α and IL-1: Pharmacological and docking studies.[J]. ACS Applied Bio Materials, 2018: e0193451. DOI: 10.1371/journal.pone.0193451
[2] NANANG FAKHRUDIN. n-Hexane Insoluble Fraction of Plantago lanceolata Exerts Anti-Inflammatory Activity in Mice by Inhibiting Cyclooxygenase-2 and Reducing Chemokines Levels.[J]. Scientia Pharmaceutica, 2017, 85 1. DOI: 10.3390/scipharm85010012
[3] WEI LI. YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer.[J]. ACS Chemical Biology, 2017: 144. DOI: 10.1186/s13046-017-0612-3
[4] RAJU GAUTAM. Rutin attenuates intestinal toxicity induced by Methotrexate linked with anti-oxidative and anti-inflammatory effects.[J]. BMC Complementary and Alternative Medicine, 2016, 16 1: 99. DOI: 10.1186/s12906-016-1069-1
[5] ARVIND KUMAR GIRI. Effect of lycopene against gastroesophageal reflux disease in experimental animals.[J]. BMC Complementary and Alternative Medicine, 2015: 110. DOI: 10.1186/s12906-015-0631-6
[6] RAQUEL TEIXEIRA FERREIRA. Mechanisms Underlying the Antinociceptive, Antiedematogenic, and Anti-Inflammatory Activity of the Main Flavonoid from Kalanchoe pinnata.[J]. Evidence-based Complementary and Alternative Medicine, 2014, 2014: 429256. DOI: 10.1155/2014/429256
[7] HEINZ FRETZ*. Identification of 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968), a Potent, Selective, and Orally Bioavailable Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTH2) Antagonist[J]. Journal of Medicinal Chemistry, 2013, 56 12: 4899-4911. DOI: 10.1021/jm400122f
[8] SEUNG HO LEE. Dual inhibition of cyclooxygenases-2 and 5-lipoxygenase by deoxypodophyllotoxin in mouse bone marrow-derived mast cells.[J]. Biological & pharmaceutical bulletin, 2004, 27 6: 786-788. DOI: 10.1248/bpb.27.786 |
| | COX (ovine) Colorimetric Inhibitor Screening Assay Kit Preparation Products And Raw materials |
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