| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Company Name: |
BOC Sciences |
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
|
| | U-63557A Basic information |
| Product Name: | U-63557A | | Synonyms: | SODIUM FUREGRELATE;U-63557A;FUREGRELATE SODIUM;FUREGRELATE SODIUM SALT;5-(3-PYRIDINYLMETHYL)-2-BENZOFURANCARBOXYLIC ACID, SODIUM SALT;5-[3,PYRIDINYLMETHYL]BENZO-FURAN-CARBOXYLIC ACID SODIUM SALT;furegralate sodium;5-(3-Pyridinylmethyl)benzofurancarboxylic acid sodium-potassium salt | | CAS: | 85666-17-7 | | MF: | C15H12NNaO3 | | MW: | 277.25 | | EINECS: | | | Product Categories: | | | Mol File: | 85666-17-7.mol |  |
| | U-63557A Chemical Properties |
| storage temp. | −20°C | | solubility | DMF: >25 mg/ml; DMSO: >21 mg/ml; Ethanol: >14.5 mg/ml; PBS pH 7.2: >16.5 mg/ml | | form | White to off-white crystalline solid. | | color | White to light yellow | | Water Solubility | Soluble in water at approximately 15mg/ml |
| | U-63557A Usage And Synthesis |
| Uses | Inhibitor (thromboxane synthetase). | | Uses | Furegrelate Sodium (U-63557A) is a selective and potent thromboxane A2 synthase (TXA2R) inhibitor in platelets. | | in vivo | Furegrelate Sodium (1-5 mg/kg; po) prevents blockage of the coronary artery[1].
Furegrelate Sodium (0.1-5 mg/kg; i.v.) prevents the blockage of stenosed coronary arteries caused platelet aggregation[1].
Furegrelate Sodium blunts the development of hypoxia-induced pulmonary arterial hypertension (PAH) in an established neonatal piglet model primarily by preserving the structural integrity of the pulmonary vasculature[2].
Furegrelate has a long half-life compared to several other drugs used to treat PAH, including nitric oxide and prostagcyclin analogues; And Furegrelate is highly specific to the target enzyme[2]. | Animal Model: | Mongrel dogs (19-30 kg)[1] | | Dosage: | 1-5 mg/kg | | Administration: | Oral (via a gastric tube) | | Result: | Prevented blockage of the coronary artery. |
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| | U-63557A Preparation Products And Raw materials |
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