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| | 2-[2-(Dimethylamino)ethoxy]ethanol Basic information |
| | 2-[2-(Dimethylamino)ethoxy]ethanol Chemical Properties |
| Boiling point | 95 °C15 mm Hg(lit.) | | density | 0.954 g/mL at 25 °C(lit.) | | vapor pressure | 11Pa at 20℃ | | refractive index | n20/D 1.442(lit.) | | Fp | 199 °F | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 14.37±0.10(Predicted) | | form | clear liquid | | color | Colorless to Light yellow to Light orange | | Water Solubility | 1000g/L at 20℃ | | Henry's Law Constant | 8.3×102 mol/(m3Pa) at 25℃, Du et al. (2017) | | Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, acids, isocyanates. | | InChI | 1S/C6H15NO2/c1-7(2)3-5-9-6-4-8/h8H,3-6H2,1-2H3 | | InChIKey | YSAANLSYLSUVHB-UHFFFAOYSA-N | | SMILES | CN(C)CCOCCO | | LogP | -0.778 at 20℃ | | CAS DataBase Reference | 1704-62-7(CAS DataBase Reference) | | NIST Chemistry Reference | ethanol, 2-[2-(dimethylamino)ethoxy]-(1704-62-7) | | EPA Substance Registry System | Ethanol, 2-[2-(dimethylamino)ethoxy]- (1704-62-7) |
| Hazard Codes | Xn | | Risk Statements | 21-41 | | Safety Statements | 26-36/37/39 | | RIDADR | NA 1993 / PGIII | | WGK Germany | 1 | | RTECS | KK6825000 | | TSCA | TSCA listed | | HS Code | 29225090 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Dermal
Eye Dam. 1 | | Toxicity | rabbit,LD50,skin,1410uL/kg (1.41mL/kg),Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974. |
| | 2-[2-(Dimethylamino)ethoxy]ethanol Usage And Synthesis |
| Chemical Properties | liquid | | Uses | Used for the preparation of low-density packaging foams. | | Flammability and Explosibility | Not classified | | Synthesis | 1. Synthesis step: 63.1 g of diethylene glycolamine (0.6 mol) and 34.5 g of paraformaldehyde (1.2 mol) were added to a 250 mL three-necked flask and stirred for 30 minutes. Subsequently, 63 g of formic acid (1.2 mol, 88%) was added slowly and dropwise. The reaction mixture was heated to 100-110°C and kept at this temperature for 1 hour. Upon completion of the reaction, 30 g of the fraction was distilled under reduced pressure (vacuum -0.094 MPa, kettle temperature 80°C). At this time, the content of the product 2-[2-(dimethylamino)ethoxy]ethanol was 90.0% and the content of impurity (S-2) was 9.8%.
2. Purification step: the above reaction solution was transferred to a 500 mL distillation flask and distilled under reduced pressure (-0.094 MPa). Firstly, the fraction at 62°C was collected, which was mainly n-butanol ester exchange product and butyl formate. Subsequently, the fraction at 121 °C, the target product 2-[2-(dimethylamino)ethoxy]ethanol, was collected, and a total of 128.3 g was obtained in 96.5% yield and 99.9% product purity. | | References | [1] Patent: CN106748831, 2017, A. Location in patent: Paragraph 0043-0058; 0064 |
| | 2-[2-(Dimethylamino)ethoxy]ethanol Preparation Products And Raw materials |
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